FN Archimer Export Format
PT J
TI The relationship between membrane fatty acid content and mitochondrial efficiency differs within- and between- omega-3 dietary treatments
BT 
AF Salin, Karine
   Mathieu-Resuge, Margaux
   Graziano, Nicolas
   Dubillot, Emmanuel
   Le Grand, Fabienne
   Soudant, Philippe
   Vagner, Marie
AS 1:1;2:2;3:1,3;4:3;5:1;6:1;7:1,3;
FF 1:PDG-RBE-PFOM-LARN;2:;3:;4:;5:;6:;7:;
C1 Univ Brest, Ifremer, CNRS, IRD, LEMAR, F-29280, Plouzané, France
   WasserCluster Lunz — Inter-University Centre for Aquatic Ecosystem Research, Dr. Carl Kupelwieser Promenade 5 A-3293 Lunz Am See, Austria
   UMR 7266 LIENSs, 2 Rue Olympe de Gouges 17000 La Rochelle, France
   Univ Brest, Ifremer, CNRS, IRD, LEMAR, F-29280, Plouzané, France
C2 IFREMER, FRANCE
   WASSERCLUSTER LUNZ, AUSTRIA
   UNIV LA ROCHELLE, FRANCE
   CNRS, FRANCE
SI BREST
SE PDG-RBE-PFOM-LARN
UM LEMAR
IN WOS Ifremer UMR
   WOS Cotutelle UMR
   copubli-france
   copubli-europe
   copubli-univ-france
IF 3.737
TC 6
UR https://archimer.ifremer.fr/doc/00658/77013/78276.pdf
LA English
DT Article
DE ;ATP/O ratio;Docosahexaenoic acid (DHA);Eicosapentaenoic acid (EPA);Food quality;Chelon auratus;Global change
AB An important, but underappreciated, consequence of climate change is the reduction in crucial nutrient production at the base of the marine food chain: the long-chain omega-3 highly unsaturated fatty acids (n-3 HUFA). This can have dramatic consequences on consumers, such as fish as they have limited capacity to synthesise n-3 HUFA de novo. The n-3 HUFA, such as docosahexaenoic acid (DHA, 22:6n-3) and eicosapentaenoic acid (EPA, 20:5n-3), are critical for the structure and function of all biological membranes. There is increasing evidence that fish will be badly affected by reductions in n-3 HUFA dietary availability, however the underlying mechanisms remain obscure. Hypotheses for how mitochondrial function should change with dietary n-3 HUFA availability have generally ignored ATP production, despite its importance to a cell's total energetics capacity, and in turn, whole-animal performance. Here we (i) quantified individual variation in mitochondrial efficiency (ATP/O ratio) of muscle and (ii) examined its relationship with content in EPA and DHA in muscle membrane of a primary consumer fish, the golden grey mullet Chelon auratus, receiving either a high or low n-3 HUFA diet. Mitochondria of fish fed on the low n-3 HUFA diet had higher ATP/O ratio than those of fish maintained on the high n-3 HUFA diet. Yet, mitochondrial efficiency varied up about 2-fold among individuals on the same dietary treatment, resulting in some fish consuming half the oxygen and energy substrate to produce the similar amount of ATP than conspecific on similar diet. This variation in mitochondrial efficiency among individuals from the same diet treatment was related to individual differences in fatty acid composition of the membranes: a high ATP/O ratio was associated with a high content in EPA and DHA in biological membranes. Our results highlight the existence of interindividual differences in mitochondrial efficiency and its potential importance in explaining intraspecific variation in response to food chain changes. 
PY 2021
PD JAN
SO Marine Environmental Research
SN 0141-1136
PU Elsevier BV
VL 163
UT 000611824400003
DI 10.1016/j.marenvres.2020.105205
ID 77013
ER

EF