FN Archimer Export Format
PT J
TI Glucagon-like peptide-1 secretagogues from the leaves of Oparanthus teikiteetinii
BT 
AF HUGUET, Clement
   OLATUNJI, Opeyemi Joshua
   REAL, Eleonore
   RAHARIVELOMANANA, Phila
   URBAIN, Aurelie
AS 1:1;2:1,4;3:2;4:3;5:1;
FF 1:;2:;3:;4:;5:;
C1 Univ Strasbourg, CNRS, IPHC UMR 7178, F-67000 Strasbourg, France.
   Univ Strasbourg, CNRS, LBP UMR 7021, F-67000 Strasbourg, France.
   Univ Polynesie Francaise, EIMS UMR 241 EIO, F-98702 Faaa Tahiti, French Polynesi, France.
   Prince Songkla Univ, Fac Tradit Thai Med, Hat Yai 90112, Thailand.
C2 UNIV STRASBOURG, FRANCE
   UNIV STRASBOURG, FRANCE
   UNIV POLYNESIE FRANCAISE, FRANCE
   UNIV PRINCE SONGKLA, THAILAND
UM EIO
IN WOS Cotutelle UMR
   copubli-france
   copubli-univ-france
   copubli-int-hors-europe
   copubli-sud
IF 1.459
TC 1
UR https://archimer.ifremer.fr/doc/00659/77127/88225.pdf
LA English
DT Article
DE ;Oparanthus teikiteetinii;Benzofuran derivatives;Coumaran;Sesquiterpene lactones;Glucagon-like peptide-1 secretion
AB In our search for natural compounds that stimulate glucagon-like peptide-1 secretion, an extract from the leaves of Oparanthus teikiteetinii (Asteraceae) was found to increase significantly GLP-1 secretion in vitro in a model cell line (mouse intestinal STC-1 cells). The phytochemical investigation of this extract resulted in the isolation of two new dihydrobenzofuran derivatives (1-2) identified as (2R)-2-(prop-1-en-2-yl)-2,3-dihydro-1-benzofuran-5-ol (1) and (2S,3R)-2-(prop-1-en-2-yl)-2,3-dihydro-1-benzofuran-3,5-diol (2). Thirteen other compounds were isolated, including eight known dihydrobenzofuran derivatives (3-10), jasopyran (11), and four sesquiterpene lactones (12-15) including a new one, grandulin (15). Their structures were established mainly by NMR and HRESIMS analysis and by comparison with data reported in the literature. Tested on STC-1 cells at the concentration of 100 mu M, compounds 7, 11, and 12 increased GLP-1 secretion by 305, 218, and 156% respectively, compared to control cells, without affecting cell viability. 
PY 2019
PD APR
SO Phytochemistry Letters
SN 1874-3900
PU Elsevier Science Bv
VL 30
UT 000461363900040
BP 201
EP 204
DI 10.1016/j.phytol.2019.02.020
ID 77127
ER

EF