FN Archimer Export Format
PT J
TI In vitro evaluation of polymeric nanoparticles with a fluorine core for drug delivery triggered by focused ultrasound
BT 
AF SOMAGLINO, Lucie
   Mousnier, L
   Giron, A
   Urbach, W
   Tsapis, N
   Taulier, N
AS 1:1;2:2;3:1;4:1,3;5:2;6:1;
FF 1:;2:;3:;4:;5:;6:;
C1 Sorbonne Université, CNRS, INSERM, Laboratoire d’Imagerie Biomédicale, LIB, F-75006 Paris, France
   Université Paris-Saclay, CNRS, Institut Galien Paris Saclay, 92296, Châtenay-Malabry, France
   Laboratoire de Physique de l’École Normale Supérieure, ENS, Université PSL, CNRS, Sorbonne Université, Université de Paris, F-75005 Paris, France
C2 UNIV SORBONNE, FRANCE
   UNIV PARIS SACLAY, FRANCE
   ENS, FRANCE
IF 5.999
TC 8
UR https://archimer.ifremer.fr/doc/00667/77875/80022.pdf
LA English
DT Article
DE ;Ultrasound;Drug delivery;Nanoparticles;PFOB;Cavitation
AB Polymeric nanoparticles are being intensively investigated as drug carriers. Their efficiency could be enhanced if the drug release can be triggered using an external stimulus such as ultrasound. This approach is possible using current commercial apparatus that combine focused ultrasound with MRI to perform ultrasonic surgery. In this approach, nanoparticles made of a perfluoro-octyl bromide core and a thick polymeric (PLGA-PEG) shell may represent suitable drug carriers. Indeed, their perfluorocarbon core are detectable by 19F MRI, while their polymeric shell can encapsulate drugs. However, their applicability in ultrasound-triggered drug delivery remains to be proven. To do so, we used Nile red as a model drug and we measured its release from the polymeric shell by spectrofluorometry. In the absence of ultrasound, only a small amount of Nile red release was measured (<5%). Insonations were performed in a controlled environment using a 1.1 MHz transducer emitting tone bursts for a few minutes, whereas a focused broadband hydrophone was used to detect the occurrence of cavitation. In the absence of detectable inertial cavitation, less than 5% of Nile red was released. In the presence of detectable inertial cavitation, Nile red release was ranging from 10 to 100%, depending of the duty cycle, acoustic pressure, and tank temperature (25 or 37°C). Highest releases were obtained only for duty cycles of 25% at 37°C and 50% at 25°C and for a peak-to-peak acoustic pressure above 12.7 MPa. Electron microscopy and light scattering measurements showed a slight modification in the nanoparticle morphology only at high release contents. The occurrence of strong inertial cavitation is thus a prerequisite to induce drug release for these nanoparticles. Since strong inertial cavitation can lead to many unwanted biological effects, these nanoparticles may not be suitable for a therapeutic application using ultrasound-triggered drug delivery. 
PY 2021
PD APR
SO Colloids And Surfaces B-biointerfaces
SN 0927-7765
PU Elsevier
VL 200
UT 000632210000001
DI 10.1016/j.colsurfb.2021.111561
ID 77875
ER

EF