FN Archimer Export Format
PT J
TI Multiple independent transmission cycles of a tick-borne pathogen within a local host community
BT 
AF JACQUOT, Maude
   ABRIAL, David
   GASQUI, Patrick
   BORD, Severine
   MARSOT, Maud
   MASSEGLIA, Sebastien
   PION, Angelique
   POUX, Valerie
   ZILLIOX, Laurence
   CHAPUIS, Jean-Louis
   VOURC'H, Gwenael
   BAILLY, Xavier
AS 1:1,4;2:1;3:1;4:1;5:1,5;6:1;7:1;8:1;9:2;10:3;11:1;12:1;
FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;11:;12:;
C1 INRA, Epidemiol Anim UR346, St Genes Champanelle, France.
   Hop Univ Strasbourg, CNR Borrelia, F-6700 Strasbourg, France.
   Univ Sorbonne, UPMC, CNRS, MNHN,Ctr Ecol & Sci Conservat, CP53,61 Rue Buffon, F-75005 Paris, France.
   Univ Glasgow, Coll Med Vet & Life Sci, Inst Biodivers Anim Hlth & Comparat Med, Glasgow G12 8QQ, Lanark, Scotland.
   ANSES, Unite Epidemiol, 14 Rue Pierre & Marie Curie, F-94706 Maisons Alfort, France.
C2 INRA, FRANCE
   UNIV STRASBOURG, FRANCE
   UNIV SORBONNE, FRANCE
   UNIV GLASGOW, UK
   ANSES, FRANCE
IN DOAJ
IF 4.259
TC 9
UR https://archimer.ifremer.fr/doc/00667/77885/80049.pdf
   https://archimer.ifremer.fr/doc/00667/77885/80050.pdf
LA English
DT Article
AB Many pathogens are maintained by multiple host species and involve multiple strains with potentially different phenotypic characteristics. Disentangling transmission patterns in such systems is often challenging, yet investigating how different host species contribute to transmission is crucial to properly assess and manage disease risk. We aim to reveal transmission cycles of bacteria within the Borrelia burgdorferi species complex, which include Lyme disease agents. We characterized Borrelia genotypes found in 488 infected Ixodes ricinus nymphs collected in the Senart Forest located near Paris (France). These genotypes were compared to those observed in three sympatric species of small mammals and network analyses reveal four independent transmission cycles. Statistical modelling shows that two cycles involving chipmunks, an introduced species, and non-sampled host species such as birds, are responsible for the majority of tick infections. In contrast, the cycle involving native bank voles only accounts for a small proportion of infected ticks. Genotypes associated with the two primary transmission cycles were isolated from Lyme disease patients, confirming the epidemiological threat posed by these strains. Our work demonstrates that combining high-throughput sequence typing with networks tools and statistical modeling is a promising approach for characterizing transmission cycles of multi-host pathogens in complex ecological settings. 
PY 2016
PD AUG
SO Scientific Reports
SN 2045-2322
PU Nature Publishing Group
VL 6
UT 000381009100001
DI 10.1038/srep31273
ID 77885
ER

EF