Marine Natural Occurring 2,5-Diketopiperazines: Isolation, Synthesis and Optical Properties

Type Article
Date 2015-01
Language English
Author(s) Laville Remi1, Thanh Binh Nguyen 1, Moriou Celine1, Petek Sylvain2, Debitus CecileORCID2, Al-Mourabit Ali1
Affiliation(s) 1 : CNRS, Inst Chim Subst Nat, Ctr Rech Gif Sur Yvette, F-91198 Gif Sur Yvette, France.
2 : Ctr Polynesie Francaise, IRD, UMR241, Papeete, France.
Source Heterocycles (0385-5414) (Pergamon-elsevier Science Ltd), 2015-01 , Vol. 90 , N. 2 , P. 1351-1366
DOI 10.3987/COM-14-S(K)87
WOS© Times Cited 11
Keyword(s) Diketopiperazine, Sponge, Marine Metabolite, Circular Dichroism

Seven 2,5-diketopiperazines (DKPs) were isolated from the Fijian marine sponge Acanthella cavernosa. NMR and circular dichroism (CD) comparison with synthetic L-L DKPs allowed us to determine unambiguously the L-L absolute configuration of the natural DKPs. This work initiated the setting up of an optical properties database of natural DKPs, including specific rotation and CD.

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