FN Archimer Export Format
PT J
TI Mutation load at a mimicry supergene sheds new light on the evolution of inversion polymorphisms
BT 
AF Jay, Paul
   Chouteau, Mathieu
   Whibley, Annabel
   Bastide, Héloïse
   Parrinello, Hugues
   Llaurens, Violaine
   Joron, Mathieu
AS 1:1;2:1,2;3:3;4:4;5:5;6:4;7:1;
FF 1:;2:;3:;4:;5:;6:;7:;
C1 CEFE, Université de Montpellier, CNRS, EPHE, IRD, Université Paul Valéry Montpellier 3, Montpellier, France
   LEEISA, Université de Guyane, CNRS, IFREMER, Cayenne, French Guiana
   School of Biological Sciences, University of Auckland, Auckland, New Zealand
   ISYEB, MNHN, CNRS, Sorbonne Universités, EPHE, Paris, France
   MGX, Biocampus Montpellier, Université de Montpellier, CNRS, INSERM, Montpellier, France
C2 UNIV MONTPELLIER, FRANCE
   UNIV GUYANE, FRANCE
   UNIV AUCKLAND, NEW ZEALAND
   MNHN, FRANCE
   UNIV MONTPELLIER, FRANCE
UM LEEISA
IN WOS Cotutelle UMR
   copubli-france
   copubli-univ-france
   copubli-int-hors-europe
IF 41.376
TC 60
UR https://archimer.ifremer.fr/doc/00677/78932/93566.pdf
LA English
DT Article
AB Chromosomal inversions are ubiquitous in genomes and often coordinate complex phenotypes, such as the covariation of behavior and morphology in many birds, fishes, insects or mammals1,2,3,4,5,6,7,8,9,10,11. However, why and how inversions become associated with polymorphic traits remains obscure. Here we show that despite a strong selective advantage when they form, inversions accumulate recessive deleterious mutations that generate frequency-dependent selection and promote their maintenance at intermediate frequency. Combining genomics and in vivo fitness analyses in a model butterfly for wing-pattern polymorphism, Heliconius numata, we reveal that three ecologically advantageous inversions have built up a heavy mutational load from the sequential accumulation of deleterious mutations and transposable elements. Inversions associate with sharply reduced viability when homozygous, which prevents them from replacing ancestral chromosome arrangements. Our results suggest that other complex polymorphisms, rather than representing adaptations to competing ecological optima, could evolve because chromosomal rearrangements are intrinsically prone to carrying recessive harmful mutations. 
PY 2021
PD MAR
SO Nature Genetics
SN 1061-4036
PU Springer Science and Business Media LLC
VL 53
IS 3
UT 000611467100002
BP 288
EP 293
DI 10.1038/s41588-020-00771-1
ID 78932
ER

EF