FN Archimer Export Format
PT J
TI Diverging patterns of introgression from Schistosoma bovis across S. haematobium African lineages
BT 
AF Rey, Olivier
   Toulza, Eve
   Chaparro, Cristian
   Allienne, Jean-François
   Kincaid-Smith, Julien
   Mathieu-Begné, Eglantine
   Allan, Fiona
   Rollinson, David
   Webster, Bonnie L.
   Boissier, Jérôme
AS 1:1;2:1;3:1;4:1;5:1,2;6:1;7:3;8:3;9:3;10:1;
FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;
C1 Univ. Montpellier, CNRS, IFREMER, UPVD, IHPE, Perpignan, France
   Centre for Emerging, Endemic and Exotic Diseases (CEEED), Department of Pathobiology and Population Sciences (PPS), Royal Veterinary College, University of London, Hawkshead Campus, Herts, United Kingdom
   Wolfson Wellcome Biomedical Laboratories, Department of Life Sciences, Natural History Museum, London, United Kingdom, London Centre for Neglected Tropical Disease Research, Imperial College London School of Public Health, London, United Kingdom
C2 UNIV MONTPELLIER, FRANCE
   UNIV LONDON, UK
   IMPERIAL COLL LONDON, UK
UM IHPE
IN WOS Cotutelle UMR
   DOAJ
   copubli-europe
IF 7.464
TC 20
UR https://archimer.ifremer.fr/doc/00678/79020/81421.pdf
   https://archimer.ifremer.fr/doc/00678/79020/81422.xlsx
   https://archimer.ifremer.fr/doc/00678/79020/81423.xlsx
   https://archimer.ifremer.fr/doc/00678/79020/81424.pdf
   https://archimer.ifremer.fr/doc/00678/79020/81425.pdf
LA English
DT Article
AB Hybridization is a fascinating evolutionary phenomenon that raises the question of how species maintain their integrity. Inter-species hybridization occurs between certain Schistosoma species that can cause important public health and veterinary issues. In particular hybrids between Schistosoma haematobium and S. bovis associated with humans and animals respectively are frequently identified in Africa. Recent genomic evidence indicates that some S. haematobium populations show signatures of genomic introgression from S. bovis. Here, we conducted a genomic comparative study and investigated the genomic relationships between S. haematobium, S. bovis and their hybrids using 19 isolates originating from a wide geographical range over Africa, including samples initially classified as S. haematobium (n = 11), S. bovis (n = 6) and S. haematobium x S. bovis hybrids (n = 2). Based on a whole genomic sequencing approach, we developed 56,181 SNPs that allowed a clear differentiation of S. bovis isolates from a genomic cluster including all S. haematobium isolates and a natural S. haematobium-bovis hybrid. All the isolates from the S. haematobium cluster except the isolate from Madagascar harbored signatures of genomic introgression from S. bovis. Isolates from Corsica, Mali and Egypt harbored the S. bovis-like Invadolysin gene, an introgressed tract that has been previously detected in some introgressed S. haematobium populations from Niger. Together our results highlight the fact that introgression from S. bovis is widespread across S. haematobium and that the observed introgression is unidirectional. 
PY 2021
PD FEB
SO Plos Pathogens
SN 1553-7366
PU Public Library of Science (PLoS)
VL 17
IS 2
UT 000617973600002
DI 10.1371/journal.ppat.1009313
ID 79020
ER

EF