FN Archimer Export Format
PT J
TI In Vitro Hair Dermal Papilla Cells Induction by Fagraea berteroana, a Tree of the Marquesan Cosmetopoeia (French Polynesia)
BT 
AF Hughes, Kristelle
   Ho, Raimana
   Chazaud, Claire
   Hermitte, Stéphanie
   Greff, Stéphane
   Butaud, Jean-François
   Filaire, Edith
   Ranouille, Edwige
   Berthon, Jean-Yves
   Raharivelomanana, Phila
AS 1:1;2:1;3:2;4:3;5:4;6:5;7:3,6;8:3;9:3;10:1;
FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;
C1 UMR EIO 241, IFREMER, ILM, IRD, Université de la Polynésie Française, BP 6570, 98702 Faaa, Tahiti, French Polynesia
   GReD Institute, Université Clermont Auvergne, CNRS, Inserm, Faculté de Médecine, CRBC, 63000 Clermont-Ferrand, France
   Greentech SA, Biopôle Clermont-Limagne, 63360 Saint-Beauzire, France
   Institut Méditerranéen de Biodiversité et d’Ecologie Marine et Continentale (IMBE), UMR 7263 CNRS, IRD, Aix Marseille Université, Avignon Université, Station Marine d’Endoume, rue de la Batterie des Lions, 13007 Marseille, France
   Consultant in Forestry and Polynesian Botany, BP 52832, 98716 Pirae, Tahiti, French Polynesia
   UMR 1019 INRA-UcA, UNH (Human Nutrition Unity), ECREIN Team, Université Clermont Auvergne, 63000 Clermont-Ferrand, France
C2 UNIV POLYNESIE FRANCAISE, FRANCE
   UNIV CLERMONT AUVERGNE, FRANCE
   GREENTECH SA, FRANCE
   UNIV AIX MARSEILLE, FRANCE
   Consultant in Forestry and Polynesian Botany, BP 52832, 98716 Pirae, Tahiti, French Polynesia
   UNIV CLERMONT AUVERGNE, FRANCE
UM EIO
IN WOS Cotutelle UMR
   DOAJ
   copubli-france
   copubli-univ-france
TC 1
UR https://archimer.ifremer.fr/doc/00678/79021/81426.pdf
   https://archimer.ifremer.fr/doc/00678/79021/81427.xlsx
LA English
DT Article
DE ;Fagraea berteroana;hair growth;ethnocosmetology;Marquesas islands;Gentianaceae
AB Fagraea berteroana is a tree used in traditional medicine in various islands of the South Pacific. Here, we studied its hair growth-inducing properties as suggested by one of its Marquesan ethno-uses in haircare. The ethyl acetate extract of the fruits of F. berteroana (FEAE) and four resulting fractions (FEAE-F0, FEAE-F1, FEAE-F2, and FEAE-F3) were tested on hair follicle dermal papilla cells to determine their cell proliferative activity. Furthermore, RT-qPCR analysis enabled gene modulation analysis, while immunostaining of the β-catenin protein was used to follow protein regulation. We found that the plant extracts induced a controlled, dose-dependent cell proliferation. FEAE-F0 simultaneously down-regulated Bone Morphogenetic Protein 2 (BMP2) mRNA expression and upregulated Cyclin-D1 (CCND1) gene expression, which suggests an involvement in the regulation of the Wnt and Transforming Growth Factor beta (TGFβ) pathways that control the hair cycle. FEAE-F0 exhibited a 1.34-fold increase of nuclear β-catenin protein. This is indicative of an active hair growth state. Thus, we conclude that FEAE-F0 could be an innovative candidate in hair care, which opens interesting leads to promote the Marquesan cosmetopoeia. 
PY 2021
PD MAR
SO Cosmetics
SN 2079-9284
PU MDPI AG
VL 8
IS 1
UT 000634389400001
DI 10.3390/cosmetics8010013
ID 79021
ER

EF