FN Archimer Export Format
PT J
TI Different survival of three populations of European sea bass (Dicentrarchus labrax) following challenge with two variants of nervous necrosis virus (NNV)
BT 
AF Barsøe, Sofie
   Allal, Francois
   Vergnet, Alain
   Vandeputte, Marc
   Olesen, Niels Jørgen
   Schmidt, Jacob Günther
   Larsen, Cathrine Agnete
   Cuenca, Argelia
   Vendramin, Niccolò
AS 1:1;2:2;3:2;4:3,4;5:1;6:1;7:1;8:1;9:1;
FF 1:;2:PDG-RBE-MARBEC-LAAAS;3:PDG-RBE-MARBEC-LSEA;4:;5:;6:;7:;8:;9:;
C1 Technical University of Denmark, Institute for Aquatic Resources, Unit for Fish and Shellfish Diseases, Kemitorvet, Building 202, DK-2800 Kgs. Lyngby, Denmark
   MARBEC, Université Montpellier, CNRS, Ifremer, IRD, Route de Maguelone, 34250 Palavas-les-Flots, France
   Université Paris-Saclay, INRAE, AgroParisTech, GABI, Domaine de Vilvert, FR78350 Jouy-en-Josas, France
   MARBEC, Université Montpellier, CNRS, Ifremer, IRD, Route de Maguelone, 34250 Palavas-les-Flots, France
C2 UNIV TECH DENMARK, DENMARK
   IFREMER, FRANCE
   INRAE, FRANCE
   INRAE, FRANCE
SI PALAVAS
SE PDG-RBE-MARBEC-LAAAS
   PDG-RBE-MARBEC-LSEA
UM MARBEC
IN WOS Ifremer UMR
   WOS Cotutelle UMR
   DOAJ
   copubli-france
   copubli-p187
   copubli-europe
IF 3.385
TC 7
UR https://archimer.ifremer.fr/doc/00678/79050/81498.pdf
   https://archimer.ifremer.fr/doc/00678/79050/81508.docx
   https://archimer.ifremer.fr/doc/00678/79050/81509.docx
   https://archimer.ifremer.fr/doc/00678/79050/81510.docx
   https://archimer.ifremer.fr/doc/00678/79050/81511.mp4
LA English
DT Article
DE ;Nervous necrosis virus;Betanodavirus;Viral enchephalo-and retinopathy;Genetic resistance;Host-pathogen interaction;Sea bass;Neurological infection
AB Viral Nervous Necrosis (VNN, also called viral encephalo- and retinopathy (VER)), is a widespread disease of marine aquaculture caused by betanodavirus (or nervous necrosis virus - NNV), a segmented positive sense RNA virus, member of the nodaviridae family. VNN affects predominantly marine fish and cause significant losses to the Mediterranean fish farming industry, including the production of European sea bass (Dicentrarchus labrax). Of the four circulating genotypes of betanodavirus, red-spotted grouper NNV (RGNNV) and the reassortant genotype red-spotted grouper/striped jack NNV (RG/SJNNV) are most prevalent in the Mediterranean. Inheritable resistance against VNN has been detected in sea bass, and selective breeding could be a mean to limit this untreatable disease. In the current study, we compare resistance to disease among three populations from the Atlantic Ocean (AT), Eastern Mediterranean (EM) and Western Mediterranean (WM), by challenge trials using both a highly pathogenic isolate of RGNNV and a lower pathogenic reassortant isolate of RG/SJNNV. The survival of the three populations were modelled with a logistic regression, and the odds ratio (OR) of surviving was calculated. The challenge with RG/SJNNV reduced the odds of surviving three-fold (OR = 0.29 [0.07-0.87]), whereas the challenge with RGNNV reduced the odds of surviving 100-fold (OR = 0.01 [0.00-0.03]). Overall, the EM population had 3.32 (1.92–5.86) times higher odds of surviving the challenge than the AT and WM stocks. All survivors were harboring viral RNA in the brain, as demonstrated by RT-qPCR. However, viral RNA levels were in average lower in survivors from the EM population in both challenges, though only significantly lower in the challenge with RG/SJNNV (p < 0.01). The survival results combined with the RT-qPCR results indicate that the EM sea bass population has a natural resistance to disease caused by RGNNV, possibly associated with limited viral entry into and/or replication in the brain. 
PY 2021
PD MAR
SO Aquaculture Reports
SN 2352-5134
PU Elsevier BV
VL 19
UT 000625315000007
DI 10.1016/j.aqrep.2021.100621
ID 79050
ER

EF