FN Archimer Export Format
PT J
TI The Pacific Oyster Mortality Syndrome, a Polymicrobial and Multifactorial Disease: State of Knowledge and Future Directions
BT 
AF PETTON, Bruno
   DESTOUMIEUX GARZON, Delphine
   PERNET, Fabrice
   Toulza, Eve
   DE LORGERIL, Julien
   DEGREMONT, Lionel
   MITTA, Guillaume
AS 1:1;2:5;3:1;4:4;5:2;6:3;7:4;
FF 1:PDG-RBE-PFOM-LPI;2:;3:PDG-RBE-PFOM-LPI;4:;5:PDG-RBE-IHPE;6:PDG-RBE-SGMM-LGPMM;7:;
C1 Ifremer, LEMAR UMR 6539, UBO/CNRS/IRD/Ifremer, Argenton-en-Landunvez, France
   IHPE, Université de Montpellier, CNRS, Ifremer, Université de Perpignan Via Domitia, Montpellier, France
   Ifremer, SG2M, LPGMM, La Tremblade, France
   IHPE, Université de Montpellier, CNRS, Ifremer, Université de Perpignan Via Domitia, Montpellier, France
   IHPE, Université de Montpellier, CNRS, Ifremer, Université de Perpignan Via Domitia, Montpellier, France
C2 IFREMER, FRANCE
   IFREMER, FRANCE
   IFREMER, FRANCE
   UNIV PERPIGNAN, FRANCE
   CNRS, FRANCE
SI ARGENTON
   BREST
   MONTPELLIER
   LA TREMBLADE
SE PDG-RBE-PFOM-LPI
   PDG-RBE-IHPE
   PDG-RBE-SGMM-LGPMM
UM LEMAR
   IHPE
IN WOS Ifremer UPR
   WOS Ifremer UMR
   WOS Cotutelle UMR
   DOAJ
   copubli-france
   copubli-univ-france
IF 8.787
TC 41
UR https://archimer.ifremer.fr/doc/00679/79158/81669.pdf
LA English
DT Article
DE ;Pacific oyster mortality syndrome;polymicrobial disease;multifactorial disease;Crassostrea gigas;OsHV-1;opportunistic bacterial pathogens
AB The Pacific oyster (Crassostreae gigas) has been introduced from Asia to numerous countries around the world during the 20th century. C. gigas is the main oyster species farmed worldwide and represents more than 98% of oyster production. The severity of disease outbreaks that affect C. gigas, which primarily impact juvenile oysters, has increased dramatically since 2008. The most prevalent disease, Pacific oyster mortality syndrome (POMS), has become panzootic and represents a threat to the oyster industry. Recently, major steps towards understanding POMS have been achieved through integrative molecular approaches. These studies demonstrated that infection by Ostreid herpesvirus type 1 µVar (OsHV-1 µvar) is the first critical step in the infectious process and leads to an immunocompromised state by altering hemocyte physiology. This is followed by dysbiosis of the microbiota, which leads to a secondary colonization by opportunistic bacterial pathogens, which in turn results in oyster death. Host and environmental factors (e.g. oyster genetics and age, temperature, food availability, and microbiota) have been shown to influence POMS permissiveness. However, we still do not understand the mechanisms by which these different factors control disease expression. The present review discusses current knowledge of this polymicrobial and multifactorial disease process and explores the research avenues that must be investigated to fully elucidate the complexity of POMS. These discoveries will help in decision-making and will facilitate the development of tools and applied innovations for the sustainable and integrated management of oyster aquaculture. 
PY 2021
PD FEB
SO Frontiers In Immunology
SN 1664-3224
PU Frontiers Media SA
VL 12
UT 000625152300001
DI 10.3389/fimmu.2021.630343
ID 79158
ER

EF