FN Archimer Export Format
PT J
TI Is mitochondrial reactive oxygen species production proportional to oxygen consumption? A theoretical consideration
BT 
AF Hou, Chen
   Metcalfe, Neil B.
   Salin, Karine
AS 1:1;2:2;3:3;
FF 1:;2:;3:PDG-RBE-PFOM-LARN;
C1 Department of Biological Sciences Missouri University of Science and Technology Rolla Missouri, USA
   Institute of Biodiversity Animal Health and Comparative Medicine Graham Kerr Building University of Glasgow Glasgow , UK
   Department of Environment and Resources Institut français de recherche pour l'exploitation de la mer Plouzané, France
C2 UNIV MISSOURI, USA
   UNIV GLASGOW, UK
   IFREMER, FRANCE
SI BREST
SE PDG-RBE-PFOM-LARN
UM LEMAR
IN WOS Ifremer UMR
   copubli-europe
   copubli-int-hors-europe
IF 4.653
TC 10
UR https://archimer.ifremer.fr/doc/00680/79188/93569.pdf
LA English
DT Article
DE ;mitochondria;respiration states;theoretical model; uncoupling;variation
AB It has been assumed that at the whole organismal level, the mitochondrial reactive oxygen species (ROS) production is proportional to the oxygen consumption. Recently, a number of researchers have challenged this assumption, based on the observation that the ROS production per unit oxygen consumed in the resting state of mitochondrial respiration is much higher than that in the active state. Here, we develop a simple model to investigate the validity of the assumption and the challenge of it. The model highlights the significance of the time budget that mitochondria operate in the different respiration states. The model suggests that under three physiologically possible conditions, the difference in ROS production per unit oxygen consumed between the respiration states does not upset the proportionality between the whole animal ROS production and oxygen consumption. The model also shows that mitochondrial uncoupling generally enhances the proportionality. 
PY 2021
PD APR
SO Bioessays
SN 0265-9247
PU Wiley
VL 43
IS 4
UT 000614700300001
DI 10.1002/bies.202000165
ID 79188
ER

EF