Marine Exopolysaccharide Complexed with Scandium Aimed as Theranostic Agents

Type Article
Date 2021-02
Language English
Author(s) Mazza Mattia1, 2, Alliot Cyrille1, 3, Sinquin CorinneORCID4, Colliec-Jouault SylviaORCID4, Reiller Pascal E.5, Huclier-Markai SandrineORCID1, 2
Affiliation(s) 1 : GIP ARRONAX, 1 rue Aronnax, CS 10112, F-44817 Nantes, CEDEX 3, France
2 : SUBATECH, 4 rue Alfred Kastler, BP 20722, 44307 Nantes, CEDEX 3, France
3 : INSERM U892-8 quai Moncousu, BP 70721, F-44007 Nantes, France
4 : IFREMER, Institut Français de Recherche pour l’exploitation de la mer, rue de l’Ile d’Yeu, BP 21105, F-44311 Nantes, CEDEX 3, France
5 : DES–Service d’Etudes Analytiques et de Réactivité des Surfaces (SEARS), Université Paris-Saclay, CEA, F-91191, Gif sur Yvette, CEDEX, France
Source Molecules (1420-3049) (MDPI AG), 2021-02 , Vol. 26 , N. 4 , P. 1143 (23p.)
DOI 10.3390/molecules26041143
WOS© Times Cited 2
Note This article belongs to the Collection Novel Drug Candidates for Anticancer Therapy: Design, Preliminary Evaluations, and Further Developments
Keyword(s) exopolysaccharides, scandium, theranostic, characterization, complexation
Abstract

Background: Exopolysaccharide (EPS) derivatives, produced by Alteromonas infernus bacterium, showed anti-metastatic properties. They may represent a new class of ligands to be combined with theranostic radionuclides, such as 47Sc/44Sc. The goal of this work was to investigate the feasibility of such coupling. (2) Methods: EPSs, as well as heparin used as a drug reference, were characterized in terms of molar mass and dispersity using Asymmetrical Flow Field-Flow Fractionation coupled to Multi-Angle Light Scattering (AF4-MALS). The intrinsic viscosity of EPSs at different ionic strengths were measured in order to establish the conformation. To determine the stability constants of Sc with EPS and heparin, a Free-ion selective radiotracer extraction (FISRE) method has been used. (3) Results: AF4-MALS showed that radical depolymerization produces monodisperse EPSs, suitable for therapeutic use. EPS conformation exhibited a lower hydrodynamic volume for the highest ionic strengths. The resulting random-coiled conformation could affect the complexation with metal for high concentration. The LogK of Sc-EPS complexes have been determined and showing that they are comparable to the Sc-Hep. (4) Conclusions: EPSs are very promising to be coupled with the theranostic pair of scandium for Nuclear Medicine.

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