FN Archimer Export Format
PT J
TI Bioactive Bromotyrosine Derivatives from the Pacific Marine Sponge Suberea clavata (Pulitzer-Finali, 1982)
BT 
AF Moriou, Céline
   Lacroix, Damien
   Petek, Sylvain
   El-Demerdash, Amr
   Trepos, Rozenn
   Leu, Tinihauarii Mareva
   Florean, Cristina
   Diederich, Marc
   Hellio, Claire
   Debitus, Cecile
   Al-Mourabit, Ali
AS 1:1;2:1;3:2;4:1;5:2;6:3;7:4;8:5;9:2;10:2;11:1;
FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;11:;
C1 CNRS, Institut de Chimie des Substances Naturelles, Université Paris-Saclay, F-91190 Gif-sur-Yvette, France
   IRD, CNRS, Ifremer, LEMAR, Univ Brest, F-29280 Plouzane, France
   IRD, Ifremer, ILM, EIO, Univ de la Polynésie française, F-98713 Papeete, French Polynesia
   Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg, 9, rue Edward Steichen, L-2540 Luxembourg, Luxembourg
   Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea
C2 CNRS, FRANCE
   IRD, FRANCE
   IRD, FRANCE
   HOP KIRCHBERG, LUXEMBOURG
   UNIV NATL SEOUL, SOUTH KOREA
UM LEMAR
   EIO
IN WOS Cotutelle UMR
   DOAJ
   copubli-france
   copubli-europe
   copubli-int-hors-europe
IF 6.085
TC 10
UR https://archimer.ifremer.fr/doc/00684/79581/82258.pdf
   https://archimer.ifremer.fr/doc/00684/79581/82259.pdf
LA English
DT Article
CR BSMS - 1
BO Alis
DE ;sponge;Verongiida;Suberea clavata;bromotyrosine;fistularin-3;acetylcholinesterase inhibition;antifouling
AB Chemical investigation of the South-Pacific marine sponge Suberea clavata led to the isolation of eight new bromotyrosine metabolites named subereins 1–8 (2–9) along with twelve known co-isolated congeners. The detailed configuration determination of the first representative major compound of this family 11-epi-fistularin-3 (11R,17S) (1) is described. Their chemical characterization was achieved by HRMS and integrated 1D and 2D NMR (nuclear magnetic resonance) spectroscopic studies and extensive comparison with literature data. For the first time, a complete assignment of the absolute configurations for stereogenic centers C-11/17 of the known members (11R,17S) 11-epi-fistularin-3 (1) and 17-deoxyfistularin-3 (10) was determined by a combination of chemical modifications, Mosher’s technology, and ECD spectroscopy. Consequently, the absolute configurations of all our new isolated compounds 2–9 were determined by the combination of NMR, Mosher’s method, ECD comparison, and chemical modifications. Interestingly, compounds 2–7 were obtained by chemical transformation of the major compound 11-epi-fistularin-3 (1). Evaluation for acetylcholinesterase inhibition (AChE), DNA methyltransferase 1 (DNMT1) modulating activity and antifouling activities using marine bacterial strains are also presented. 
PY 2021
PD MAR
SO Marine Drugs
SN 1660-3397
PU MDPI AG
VL 19
IS 3
UT 000633826900001
DI 10.3390/md19030143
ID 79581
ER

EF