FN Archimer Export Format
PT J
TI The insecticide permethrin induces transgenerational behavioral changes linked to transcriptomic and epigenetic alterations in zebrafish (Danio rerio)
BT 
AF Blanc, Mélanie
   Antczak, Philipp
   Cousin, Xavier
   Grunau, Christoph
   Scherbak, Nikolai
   Rüegg, Joëlle
   Keiter, Steffen H.
AS 1:1,2,3;2:4;3:2,3;4:5;5:1,6;6:7;7:1;
FF 1:;2:;3:;4:;5:;6:;7:;
C1 Man-Technology-Environment Research Centre (MTM), School of Science and Technology, Örebro University, Fakultetsgatan 1, S-701 82 Örebro, Sweden
   MARBEC, University of Montpellier, CNRS, Ifremer, IRD, Palavas, France
   Université Paris-Saclay, AgroParisTech, INRAE, GABI, Domaine de Vilvert, F-78350 Jouy-en-Josas, France
   Centre for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany
   IHPE, Univ. Montpellier, CNRS, Ifremer, Univ. Perpignan Via Domitia, Perpignan, France
   Örebro Life Science Centre, School of Science and Technology, Örebro University, Fakultetsgatan 1, S-701 82 Örebro, Sweden
   Department of Organismal Biology, Uppsala University, Norbyv. 18A, 75236 Uppsala, Sweden
C2 UNIV OREBRO, SWEDEN
   INRAE, FRANCE
   UNIV PARIS SACLAY, FRANCE
   UNIV COLOGNE, GERMANY
   UNIV PERPIGNAN, FRANCE
   UNIV OREBRO, SWEDEN
   UNIV UPPSALA, SWEDEN
UM MARBEC
   IHPE
IN WOS Cotutelle UMR
   copubli-france
   copubli-europe
   copubli-univ-france
IF 10.754
TC 16
UR https://archimer.ifremer.fr/doc/00685/79661/82425.pdf
   https://archimer.ifremer.fr/doc/00685/79661/82572.docx
   https://archimer.ifremer.fr/doc/00685/79661/82573.xlsx
LA English
DT Article
DE ;Transgenerational epigenetic inheritance;Developmental neurotoxicity;Glutamatergic signaling;DNA methylation;Pesticide
AB The pyrethroid insecticide permethrin is widely used for agricultural and domestic purposes. Previous data indicated that it acts as a developmental neurotoxicant and can induce transgenerational effects in non-target organisms. However, associated underlying mechanisms remain unclear. The aim of this study was to investigate permethrin-related transgenerational effects in the zebrafish model, and to identify possible molecular mechanisms underlying inheritance. Zebrafish (F0) were exposed to permethrin during early-life (2 h post-fertilization up to 28 days). The F1 and F2 offspring generations were obtained by pairing exposed F0 males and females, and were bred unexposed. Locomotor and anxiety behavior were investigated, together with transcriptomic and epigenomic (DNA methylation) changes in brains. Permethrin exposed F0 fish were hypoactive at adulthood, while males from the F1 and F2 generations showed a specific decrease in anxiety-like behavior. In F0, transcriptomic data showed enrichment in pathways related to glutamatergic synapse activity, which may partly underlie the behavioral effects. In F1 and F2 males, dysregulation of similar pathways was observed, including a subset of differentially methylated regions that were inherited from the F0 to the F2 generation and indicated stable dysregulation of glutamatergic signaling. Altogether, the present results provide novel evidence on the transgenerational neurotoxic effects of permethrin, as well as mechanistic insight: a transient exposure induces persistent transcriptional and DNA methylation changes that may translate into transgenerational alteration of glutamatergic signaling and, thus, into behavioral alterations. 
PY 2021
PD JUN
SO Science Of The Total Environment
SN 0048-9697
PU Elsevier BV
VL 779
UT 000655687200016
DI 10.1016/j.scitotenv.2021.146404
ID 79661
ER

EF