FN Archimer Export Format
PT J
TI Case report of osteomyelitis of the mandible in osteopetrosis and management considerations
BT 
AF Allal, Sarah
   Rabuel, Valentin
   Gengler, Charline
   Douchet, Catherine
   Allal, Francois
   Zwetyenga, Narcisse
AS 1:1;2:1;3:1;4:2;5:3;6:1,4;
FF 1:;2:;3:;4:;5:;6:;
C1 Department of maxillofacial and oral surgery, University Hospital of Dijon, 2 boulevard du Maréchal de Lattre de Tassigny, BP 77908, 21079, Dijon cedex, France
   Department of Pathology, University Hospital of Dijon, Dijon, France
   MARBEC, Univ. Montpellier, Ifremer, CNRS, IRD, 34250, Palavas-les-Flots, France
   CIC-EC 1432 (Centre d'Investigation Clinique - Epidémiologie clinique) - Pr QUANTIN Catherine, Chirurgie endocrinienne, Dr GOUDET Pierre, France
C2 HOP DIJON, FRANCE
   HOP DIJON, FRANCE
   MARBEC, Univ. Montpellier, Ifremer, CNRS, IRD, 34250, Palavas-les-Flots, France
   CIC-EC 1432, FRANCE
TC 4
UR https://archimer.ifremer.fr/doc/00686/79816/82611.pdf
   https://archimer.ifremer.fr/doc/00686/79816/82612.jpg
   https://archimer.ifremer.fr/doc/00686/79816/82613.jpg
   https://archimer.ifremer.fr/doc/00686/79816/82614.jpg
   https://archimer.ifremer.fr/doc/00686/79816/82615.jpg
   https://archimer.ifremer.fr/doc/00686/79816/82616.jpg
   https://archimer.ifremer.fr/doc/00686/79816/82617.jpg
LA English
DT Article
DE ;Osteomyelitis;Mandible;Case report;Osteopetrosis;Management
AB Introduction and importance Osteopetrosis is a poorly known and probably underdiagnosed pathology. It is caused by various genetic abnormalities resulting in osteoclast dysfunction. Functional and aesthetic consequences have a major impact on the patient’s quality of life. Ten percent of osteopetrosis cases develop osteomyelitis that usually involves the mandible. Management of this complication remains complex and often unsatisfactory. Case presentation We report a case of a 62-year-old woman with osteopetrosis, complicated by mandibular osteomyelitis with intra-oral bone exposure and submental fistulas. Management was performed with antibiotic therapy and surgical necrotic resection. This cured the fistulas but the bone exposure persisted. Discussion This case report highlights the difficulty of achieving complete healing of osteomyelitis in osteopetrosis. Antibiotic therapy, surgical management, or even hyperbaric oxygen therapy are required, but must be adapted to the case. A free flap procedure is undesirable but, when it is necessary, a bone marrow transplant could be considered to restore osteoclast function. Conclusion The management of mandibular osteomyelitis in patients with osteopetrosis must adapt to the situation and severity. To avoid most cases of osteomyelitic complications in patients suffering from osteopetrosis, we propose that a preventive strategy of better dental care should be considered. 
PY 2021
SO International Journal Of Surgery Case Reports
SN 2210-2612
PU Elsevier BV
VL 81
UT 000636326200101
DI 10.1016/j.ijscr.2021.105813
ID 79816
ER

EF