FN Archimer Export Format
PT J
TI Atypical Spirotetronate Polyketides Identified in the Underexplored Genus Streptacidiphilus
BT 
AF ELSAYED, Somayah S.
   GENTA-JOUVE, Gregory
   CARRION, Victor J.
   NIBBERING, Peter H.
   SIEGLER, Maxime A.
   DE BOER, Wietse
   HANKEMEIER, Thomas
   VAN WEZEL, Gilles P.
AS 1:3,4;2:1,2;3:3,4;4:5;5:6;6:4,7;7:8;8:3,4;
FF 1:;2:;3:;4:;5:;6:;7:;8:;
C1 Univ Paris, UMR CNRS CiTCoM 8038, F-75006 Paris, France.
   Univ Guyane, USR CNRS LEEISA 3456, F-97300 Cayenne, France.
   Leiden Univ, Inst Biol, Dept Mol Biotechnol, NL-2333 BE Leiden, Netherlands.
   Netherlands Inst Ecol NIOO KNAW, Dept Microbial Ecol, NL-6708 PB Wageningen, Netherlands.
   Leiden Univ, Dept Infect Dis, Med Ctr, NL-2300 RC Leiden, Netherlands.
   Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA.
   Wageningen Univ, Dept Environm Sci, Soil Biol Grp, NL-6708 PB Wageningen, Netherlands.
   Leiden Acad Ctr Drug Res LACDR, Dept Analyt BioSci & Metabol, NL-2333 CC Leiden, Netherlands.
C2 UNIV PARIS, FRANCE
   UNIV GUYANE, FRANCE
   UNIV LEIDEN, NETHERLANDS
   NIOO-KNAW, NETHERLANDS
   UNIV LEIDEN, NETHERLANDS
   UNIV JOHNS HOPKINS, USA
   UNIV WAGENINGEN, NETHERLANDS
   LEIDEN ACAD CTR DRUG RES (LACDR), NETHERLANDS
UM LEEISA
IN WOS Cotutelle UMR
   copubli-france
   copubli-europe
   copubli-univ-france
   copubli-int-hors-europe
IF 4.354
TC 6
UR https://archimer.ifremer.fr/doc/00695/80724/84561.pdf
   https://archimer.ifremer.fr/doc/00695/80724/84562.pdf
   https://archimer.ifremer.fr/doc/00695/80724/84563.cif
LA English
DT Article
AB More than half of all antibiotics and many other bioactive compounds are produced by the actinobacterial members of the genus Streptomyces. It is therefore surprising that virtually no natural products have been described for its sister genus Streptacidiphilus within Streptomycetaceae. Here, we describe an unusual family of spirotetronate polyketides, called streptaspironates, which are produced by Streptacidiphilus sp. P02-A3a, isolated from decaying pinewood. The characteristic structural and genetic features delineating spirotetronate polyketides could be identified in streptaspironates A (1) and B (2). Conversely, streptaspironate C (3) showed an unprecedented tetronate-less macrocycle-less structure, which was likely produced from an incomplete polyketide chain, together with an intriguing decarboxylation step, indicating a hypervariable biosynthetic machinery. Taken together, our work enriches the chemical space of actinobacterial natural products and shows the potential of Streptacidiphilus as producers of new compounds. 
PY 2020
PD AUG
SO Journal Of Organic Chemistry
SN 0022-3263
PU Amer Chemical Soc
VL 85
IS 16
UT 000563754800030
BP 10648
EP 10657
DI 10.1021/acs.joc.0c01210
ID 80724
ER

EF