FN Archimer Export Format
PT J
TI Yeast-Based Biosensors: Current Applications and New Developments
BT 
AF MARTIN-YKEN, Helene
AS 1:1,2,3,4;
FF 1:;
C1 Inst Natl Rech Agr Alimentat & Environm INRAE, UMR 792, Toulouse Biotechnol Inst TBI, F-31400 Toulouse, France.
   Inst Rech Dev IRD, F-98702 Tahiti, French Polynesi, France.
   Univ Polynesie Francaise, Unite Mixte Rech Ecosyst Insulaires & Oceaniens 2, F-98702 Tahiti, French Polynesi, France.
   Inst Louis Malarde, Lab Rech Biotoxines Marines, F-98713 Tahiti, French Polynesi, France.
C2 INRAE, FRANCE
   IRD, FRANCE
   UNIV POLYNESIE FRANCAISE, FRANCE
   INST LOUIS MALARDE, FRANCE
UM EIO
IN WOS Cotutelle UMR
   DOAJ
   copubli-france
IF 5.743
TC 19
UR https://archimer.ifremer.fr/doc/00695/80737/84544.pdf
LA English
DT Article
DE ;yeasts;biosensors;cell signaling;environmental contaminants;detection
AB Biosensors are regarded as a powerful tool to detect and monitor environmental contaminants, toxins, and, more generally, organic or chemical markers of potential threats to human health. They are basically composed of a sensor part made up of either live cells or biological active molecules coupled to a transducer/reporter technological element. Whole-cells biosensors may be based on animal tissues, bacteria, or eukaryotic microorganisms such as yeasts and microalgae. Although very resistant to adverse environmental conditions, yeasts can sense and respond to a wide variety of stimuli. As eukaryotes, they also constitute excellent cellular models to detect chemicals and organic contaminants that are harmful to animals. For these reasons, combined with their ease of culture and genetic modification, yeasts have been commonly used as biological elements of biosensors since the 1970s. This review aims first at giving a survey on the different types of yeast-based biosensors developed for the environmental and medical domains. We then present the technological developments currently undertaken by academic and corporate scientists to further drive yeasts biosensors into a new era where the biological element is optimized in a tailor-made fashion by in silico design and where the output signals can be recorded or followed on a smartphone. 
PY 2020
PD MAY
SO Biosensors
SN 2079-6374
PU Biosensors-baselMdpi
VL 10
IS 5
UT 000541561700002
DI 10.3390/bios10050051
ID 80737
ER

EF