FN Archimer Export Format
PT J
TI The Spatiotemporal Dynamics and Microevolution Events That Favored the Success of the Highly Clonal Multidrug-Resistant Monophasic Salmonella Typhimurium Circulating in Europe
BT 
AF Cadel-Six, Sabrina
   Cherchame, Emeline
   Douarre, Pierre-Emmanuel
   Tang, Yue
   Felten, Arnaud
   Barbet, Pauline
   Litrup, Eva
   Banerji, Sangeeta
   Simon, Sandra
   Pasquali, Federique
   Gourmelon, Michele
   Mensah, Nana
   Borowiak, Maria
   Mistou, Michel-Yves
   Petrovska, Liljana
AS 1:1;2:1;3:1;4:2;5:1;6:1;7:3;8:4;9:4;10:5;11:6;12:2;13:7;14:8;15:2;
FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;11:PDG-RBE-SGMM-LSEM;12:;13:;14:;15:;
C1 Anses, Laboratory for Food Safety, Salmonella and Listeria Unit, Maisons-Alfort, France
   Department of Bacteriology, Animal and Plant Health Agency, Addlestone, United Kingdom
   Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark
   Robert Koch-Institute, Division of Enteropathogenic Bacteria and Legionella (FG11)/National Reference Centre for Salmonella and Other Bacterial Enteric Pathogens, Wernigerode, Germany
   Department of Agricultural and Food Sciences, Alma Mater Studiorum – University of Bologna, Bologna, Italy
   Ifremer, RBE, SGMM, Health, Environment and Microbiology Laboratory, Plouzané, France
   Department for Biological Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany
   Université Paris-Saclay, INRAE, Centre International de Ressource Microbienne (CIRM) MaIAGE, Jouy-en-Josas, France
C2 ANSES, FRANCE
   APHA, UK
   INST STATENS SERUM, DENMARK
   INST ROBERT KOCH, GERMANY
   UNIV BOLOGNA, ITALY
   IFREMER, FRANCE
   BFR, GERMANY
   UNIV PARIS SACLAY, FRANCE
SI BREST
SE PDG-RBE-SGMM-LSEM
IN WOS Ifremer UPR
   DOAJ
   copubli-france
   copubli-europe
   copubli-univ-france
IF 6.064
TC 15
UR https://archimer.ifremer.fr/doc/00696/80854/84480.pdf
   https://archimer.ifremer.fr/doc/00696/80854/84481.xlsx
   https://archimer.ifremer.fr/doc/00696/80854/84482.xlsx
   https://archimer.ifremer.fr/doc/00696/80854/84484.xlsx
   https://archimer.ifremer.fr/doc/00696/80854/84485.xlsx
   https://archimer.ifremer.fr/doc/00696/80854/84486.xlsx
   https://archimer.ifremer.fr/doc/00696/80854/84487.xlsx
   https://archimer.ifremer.fr/doc/00696/80854/84488.xlsx
   https://archimer.ifremer.fr/doc/00696/80854/84489.xlsx
   https://archimer.ifremer.fr/doc/00696/80854/84490.xlsx
LA English
DT Article
DE ;epidemic monophasic Typhimurium;core and accessory genome phylogenetic analyses;Bayesian analysis;plasmidome;resistome;microevolution European study
AB The European epidemic monophasic variant of Salmonella enterica serovar Typhimurium (S. 1,4,[5],12:i:-) characterized by the multi locus sequence type ST34 and the antimicrobial resistance ASSuT profile has become one of the most common serovars in Europe (EU) and the United States (US). In this study, we reconstructed the time-scaled phylogeny and evolution of this Salmonella in Europe. The epidemic S. 1,4,[5],12:i:- ST34 emerged in the 1980s by an acquisition of the Salmonella Genomic Island (SGI)-4 at the 3′ end of the phenylalanine phe tRNA locus conferring resistance to copper and arsenic toxicity. Subsequent integration of the Tn21 transposon into the fljAB locus gave resistance to mercury toxicity and several classes of antibiotics used in food-producing animals (ASSuT profile). The second step of the evolution occurred in the 1990s, with the integration of mTmV and mTmV-like prophages carrying the perC and/or sopE genes involved in the ability to reduce nitrates in intestinal contents and facilitate the disruption of the junctions of the host intestinal epithelial cells. Heavy metals are largely used as food supplements or pesticide for cultivation of seeds intended for animal feed so the expansion of the epidemic S. 1,4,[5],12:i:- ST34 was strongly related to the multiple-heavy metal resistance acquired by transposons, integrative and conjugative elements and facilitated by the escape until 2011 from the regulatory actions applied in the control of S. Typhimurium in Europe. The genomic plasticity of the epidemic S. 1,4,[5],12:i:- was demonstrated in our study by the analysis of the plasmidome. We were able to identify plasmids harboring genes mediating resistance to phenicols, colistin, and fluoroquinolone and also describe for the first time in six of the analyzed genomes the presence of two plasmids (pERR1744967-1 and pERR2174855-2) previously described only in strains of enterotoxigenic Escherichia coli and E. fergusonii. 
PY 2021
PD MAY
SO Frontiers In Microbiology
SN 1664-302X
PU Frontiers Media SA
VL 12
UT 000657675500001
DI 10.3389/fmicb.2021.651124
ID 80854
ER

EF