FN Archimer Export Format
PT J
TI Development in the European flounder (Platichthys flesus) of a q-PCR assay for the measurement of telomere length, a potential biomarker of pollutant effects for biomonitoring studies
BT 
AF Akcha, Farida
   Cahuc, C.
   ROUXEL, Julien
   Munschy, Catherine
   Aminot, Yann
   Chouvelon, Tiphaine
   Mahe, Kelig
   Budzinski, H.
   Mauffret, Aourell
AS 1:1;2:1;3:1;4:1;5:1;6:1;7:2;8:3;9:1;
FF 1:PDG-RBE-BE-LEX;2:;3:PDG-RBE-BE-LEX;4:PDG-RBE-BE-LBCO;5:PDG-RBE-BE-LBCO;6:PDG-RBE-BE-LBCM;7:PDG-RBE-HMMN;8:;9:PDG-RBE-BE;
C1 Ifremer, Biogeochemistry and Ecotoxicology Research Unit, Nantes, France
   Ifremer, Laboratory of Fisheries Resources, Boulogne-Sur-Mer, France
   UMR CNRS 5805 EPOC, Laboratory of Physico- and Toxico-Chemistry of the Environment, Bordeaux, France
C2 IFREMER, FRANCE
   IFREMER, FRANCE
   UNIV BORDEAUX, FRANCE
SI NANTES
   BOULOGNE
SE PDG-RBE-BE-LEX
   PDG-RBE-BE-LBCO
   PDG-RBE-BE-LBCM
   PDG-RBE-HMMN
   PDG-RBE-BE
IN WOS Ifremer UPR
   copubli-france
   copubli-univ-france
IF 7.001
TC 1
UR https://archimer.ifremer.fr/doc/00700/81161/85574.pdf
LA English
DT Article
DE ;Flatfish;Pollution;Biomonitoring;Telomere;Genotoxicity;DNA damage
AB Telomeres protect the coding sequence of chromosome ends and Telomere Length (TL) has been proposed as a biomarker of cellular aging, cumulative stress exposure and life-span in humans. With the aim to propose new biomarkers, a q-PCR protocol was adapted for the measurement of TL in the European flounder Platichthys flesus. The protocol was then applied in 2-year-old flounders from the Seine Estuary. The absolute TL in the flounder is 54 ± 13 kbp per genome (mean ± standard error). Considering relative or absolute TL, no correlation was observed with DNA damage and any of the measured contaminant concentrations (trace elements, metabolites of polycyclic aromatic hydrocarbons, polychlorobiphenyls, organochlorinated pesticides, polybrominated diphenyl ethers, perfluoroalkyl substances). Because sampling was limited, further investigations are required to state a possible impact of chemical pollution on flatfish telomeres. This is motivated by correlations observed with organochlorinated compounds when decreasing statistical significance (p ≤ 0.10). 
PY 2021
PD SEP
SO Marine Pollution Bulletin
SN 0025-326X
PU Elsevier BV
VL 170
UT 000685500400005
DI 10.1016/j.marpolbul.2021.112610
ID 81161
ER

EF