FN Archimer Export Format
PT J
TI Monitoring the Emergence of Algal Toxins in Shellfish: First Report on Detection of Brevetoxins in French Mediterranean Mussels
BT 
AF Amzil, Zouher
   Derrien, Amelie
   Terre Terrillon, Aouregan
   Duval, Audrey
   Connes, Coralie
   Marco-Miralles, Francoise
   Nézan, Elisabeth
   Mertens, Kenneth
AS 1:1;2:2;3:2;4:2;5:3;6:4;7:5;8:2;
FF 1:PDG-ODE-DYNECO-PHYC;2:PDG-ODE-LITTORAL-LERBO;3:PDG-ODE-LITTORAL-LERBO;4:PDG-ODE-LITTORAL-LERBO;5:PDG-ODE-LITTORAL-LERPAC;6:PDG-ODE-LITTORAL-LERPAC;7:;8:PDG-ODE-LITTORAL-LERBO;
C1 Ifremer (French Research Institute for Exploitation of the Sea), F-44311 Nantes, France
   Ifremer, LITTORAL, F-29900 Concarneau, France
   Ifremer, Station de Corse, F-20600 Bastia, France
   Ifremer, Centre Méditerranée, F-83507 La Seyne-sur-Mer, France
   National Museum of Natural History, DGD-REVE, Station de Biologie Marine de Concarneau, F-29900 Concarneau, France
C2 IFREMER, FRANCE
   IFREMER, FRANCE
   IFREMER, FRANCE
   IFREMER, FRANCE
   MNHN, FRANCE
SI NANTES
   CONCARNEAU
   CORSE
   TOULON
SE PDG-ODE-DYNECO-PHYC
   PDG-ODE-LITTORAL-LERBO
   PDG-ODE-LITTORAL-LERPAC
IN WOS Ifremer UPR
   DOAJ
   copubli-france
IF 6.085
TC 14
UR https://archimer.ifremer.fr/doc/00705/81739/86386.pdf
LA English
DT Article
DE ;lipophilic toxins;LC-MS;MS;brevetoxins;molluscs;Karenia;BTXs producer
AB In France, four groups of lipophilic toxins are currently regulated: okadaic acid/dinophysistoxins, pectenotoxins, yessotoxins and azaspiracids. However, many other families of toxins exist, which can be emerging toxins. Emerging toxins include both toxins recently detected in a specific area of France but not regulated yet (e.g., cyclic imines, ovatoxins) or toxins only detected outside of France (e.g., brevetoxins). To anticipate the introduction to France of these emerging toxins, a monitoring program called EMERGTOX was set up along the French coasts in 2018. The single-laboratory validation of this approach was performed according to the NF V03-110 guidelines by building an accuracy profile. Our specific, reliable and sensitive approach allowed us to detect brevetoxins (BTX-2 and/or BTX-3) in addition to the lipophilic toxins already regulated in France. Brevetoxins were detected for the first time in French Mediterranean mussels (Diana Lagoon, Corsica) in autumn 2018, and regularly every year since during the same seasons (autumn, winter). The maximum content found was 345 µg (BTX-2 + BTX-3)/kg in mussel digestive glands in November 2020. None were detected in oysters sampled at the same site. In addition, a retroactive analysis of preserved mussels demonstrated the presence of BTX-3 in mussels from the same site sampled in November 2015. The detection of BTX could be related to the presence in situ at the same period of four Karenia species and two raphidophytes, which all could be potential producers of these toxins. Further investigations are necessary to understand the origin of these toxins. 
PY 2021
PD JUN
SO Marine Drugs
SN 1660-3397
PU MDPI AG
VL 19
IS 7
UT 000676159900001
DI 10.3390/md19070393
ID 81739
ER

EF