FN Archimer Export Format
PT J
TI Genomic Diversity of the Ostreid Herpesvirus Type 1 Across Time and Location and Among Host Species
BT 
AF Morga, Benjamin
   Jacquot, Maude
   Pelletier, Camille
   Chevignon, Germain
   Dégremont, Lionel
   Biétry, Antoine
   Pepin, Jean-Francois
   Heurtebise, Serge
   Escoubas, Jean Michel
   Bean, Tim P.
   Rosani, Umberto
   Bai, Chang-Ming
   Renault, Tristan
   Lamy, Jean-Baptiste
AS 1:1;2:1;3:1;4:1;5:1;6:1;7:2;8:1;9:3;10:4,5;11:6;12:7;13:8;14:1;
FF 1:PDG-RBE-SGMM-LGPMM;2:PDG-RBE-SGMM-LGPMM;3:PDG-RBE-SGMM-LGPMM;4:PDG-RBE-SGMM-LGPMM;5:PDG-RBE-SGMM-LGPMM;6:PDG-RBE-SG2M-LGPMM;7:PDG-ODE-LITTORAL-LERPC;8:PDG-RBE-SGMM-LGPMM;9:;10:;11:;12:;13:PDG-RBE;14:PDG-RBE-SGMM-LGPMM;
C1 Ifremer, RBE-SGMM-LGPMM, La Tremblade, France
   Ifremer, ODE-Littoral-Laboratoire Environnement Ressources des Pertuis Charentais (LER-PC), La Tremblade, France
   IHPE, CNRS, Ifremer, Université de Montpellier – Université de Perpignan Via Domitia, Montpellier, France
   The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, United Kingdom
   Centre for Environment, Fisheries and Aquaculture Science, Weymouth, United Kingdom
   Department of Biology, University of Padua, Padua, Italy
   Yellow Sea Fisheries Research Institute, CAFS, Qingdao, China
   Ifremer, RBE, Nantes, France
C2 IFREMER, FRANCE
   IFREMER, FRANCE
   CNRS, FRANCE
   UNIV EDINBURGH, UK
   CEFAS, UK
   UNIV PADUA, ITALY
   CHINESE ACAD SCI, CHINA
   IFREMER, FRANCE
SI LA TREMBLADE
   NANTES
SE PDG-RBE-SGMM-LGPMM
   PDG-RBE-SG2M-LGPMM
   PDG-ODE-LITTORAL-LERPC
   PDG-RBE
UM IHPE
IN WOS Ifremer UPR
   WOS Cotutelle UMR
   DOAJ
   copubli-france
   copubli-europe
   copubli-int-hors-europe
   copubli-sud
IF 6.064
TC 9
UR https://archimer.ifremer.fr/doc/00706/81762/86449.pdf
   https://archimer.ifremer.fr/doc/00706/81762/86451.zip
LA English
DT Article
DE ;marine virus;OsHV-1;diversity;shellfish farming;measurably evolution
AB The mechanisms underlying virus emergence are rarely well understood, making the appearance of outbreaks largely unpredictable. This is particularly true for pathogens with low per-site mutation rates, such as DNA viruses, that do not exhibit a large amount of evolutionary change among genetic sequences sampled at different time points. However, whole-genome sequencing can reveal the accumulation of novel genetic variation between samples, promising to render most, if not all, microbial pathogens measurably evolving and suitable for analytical techniques derived from population genetic theory. Here, we aim to assess the measurability of evolution on epidemiological time scales of the Ostreid herpesvirus 1 (OsHV-1), a double stranded DNA virus of which a new variant, OsHV-1 μVar, emerged in France in 2008, spreading across Europe and causing dramatic economic and ecological damage. We performed phylogenetic analyses of heterochronous (n = 21) OsHV-1 genomes sampled worldwide. Results show sufficient temporal signal in the viral sequences to proceed with phylogenetic molecular clock analyses and they indicate that the genetic diversity seen in these OsHV-1 isolates has arisen within the past three decades. OsHV-1 samples from France and New Zealand did not cluster together suggesting a spatial structuration of the viral populations. The genome-wide study of simple and complex polymorphisms shows that specific genomic regions are deleted in several isolates or accumulate a high number of substitutions. These contrasting and non-random patterns of polymorphism suggest that some genomic regions are affected by strong selective pressures. Interestingly, we also found variant genotypes within all infected individuals. Altogether, these results provide baseline evidence that whole genome sequencing could be used to study population dynamic processes of OsHV-1, and more broadly herpesviruses. 
PY 2021
PD JUN
SO Frontiers In Microbiology
SN 1664-302X
PU Frontiers Media SA
VL 12
UT 000678429900001
DI 10.3389/fmicb.2021.711377
ID 81762
ER

EF