FN Archimer Export Format
PT J
TI Amphiphilic and Perfluorinated Poly(3-Hydroxyalkanoate) Nanocapsules for 19F Magnetic Resonance Imaging
BT 
AF Le Gal, Marion
   Renard, Estelle
   Simon-Colin, Christelle
   Larrat, Benoit
   Langlois, Valérie
AS 1:1,2;2:2;3:1;4:3;5:2;
FF 1:PDG-REM-EEP-LMEE;2:;3:PDG-REM-EEP-LMEE;4:;5:;
C1 Laboratoire de Microbiologie des Environnements Extrêmes, CNRS, Ifremer, University Brest, F-29280 Plouzané, France
   ICMPE, CNRS, University Paris Est Creteil, F-94010 Creteil, France
   Université Paris-Saclay, CEA, CNRS, NeuroSpin, 91191 Gif-sur-Yvette, France
C2 IFREMER, FRANCE
   CNRS, FRANCE
   CEA, FRANCE
SI BREST
SE PDG-REM-EEP-LMEE
UM BEEP-LM2E
IN WOS Ifremer UMR
   DOAJ
   copubli-france
IF 5.046
TC 2
UR https://archimer.ifremer.fr/doc/00722/83394/88368.pdf
   https://archimer.ifremer.fr/doc/00722/83394/88369.zip
LA English
DT Article
DE ;polyhydroxyalkanoates;mcl-PHA;nanocapsules;fluorinated polymer;amphiphilic copolymer
AB Nanoparticles have recently emerged as valuable tools in biomedical imaging techniques. Here PEGylated and fluorinated nanocapsules based on poly(3-hydroxyalkanoate) containing a liquid core of perfluorooctyl bromide PFOB were formulated by an emulsion-evaporation process as potential 19F MRI imaging agents. Unsaturated poly(hydroxyalkanoate), PHAU, was produced by marine bacteria using coprah oil and undecenoic acid as substrates. PHA-g-(F; PEG) was prepared by two successive controlled thiol-ene reactions from PHAU with firstly three fluorinated thiols having from 3 up to 17 fluorine atoms and secondly with PEG-SH. The resulting PHA-g-(F; PEG)-based PFOB nanocapsules, with a diameter close to 250–300 nm, are shown to be visible in 19F MRI with an acquisition time of 15 min. The results showed that PFOB-nanocapsules based on PHA-g-(F; PEG) have the potential to be used as novel contrast agents for 19F MRI. 
PY 2021
PD SEP
SO Bioengineering-basel
SN 2306-5354
PU MDPI AG
VL 8
IS 9
UT 000699376400001
DI 10.3390/bioengineering8090121
ID 83394
ER

EF