FN Archimer Export Format
PT J
TI Guidance Level for Brevetoxins in French Shellfish
BT 
AF Arnich, Nathalie
   Abadie, Eric
   Amzil, Zouher
   Dechraoui Bottein, Marie-Yasmine
   Comte, Katia
   Chaix, Estelle
   Delcourt, Nicolas
   Hort, Vincent
   Mattei, César
   Molgó, Jordi
   Le Garrec, Raphaele
AS 1:1;2:2;3:3;4:4;5:5;6:1;7:6;8:7;9:8;10:9;11:10;
FF 1:;2:PDG-ODE-LITTORAL-LERLR;3:PDG-ODE-DYNECO-PHYC;4:;5:;6:;7:;8:;9:;10:;11:;
C1 ANSES (French Agency for Food, Environmental and Occupational Health and Safety), Risk Assessment Directorate, 94701 Maisons-Alfort, France
   MARBEC (MARine Biodiversity, Exploitation and Conservation), Université de Montpellier, CNRS, Ifremer, IRD, 34200 Sète, Franc
   Ifremer (French Research Institute for Exploitation of the Sea), 44311 Nantes, France
   Université Côte d’Azur, CNRS, ECOSEAS, UMR7035, Parc Valrose, 06108 Nice, France
   UMR7245 MCAM CNRS-MNHN, Muséum National d’Histoire Naturelle, 75231 Paris, France
   Poison Control Centre, Toulouse-Purpan University Hospital and Toulouse NeuroImaging Centre (ToNIC), INSERM 1214, 31059 Toulouse, France
   ANSES (French Agency for Food, Environmental and Occupational Health and Safety), Laboratory for Food Safety, Pesticides and Marine Biotoxins Unit, 94701 Maisons-Alfort, France
   University of Angers, INSERM, CNRS, MITOVASC, Equipe CarMe, SFR ICAT, 49100 Angers, France
   CEA (French Alternative Energies and Atomic Energy Commission), INRAE, University of Paris-Saclay, DMTS, SIMoS, ERL CNRS 9004, 91191 Gif sur Yvette, France
   Laboratoire Interactions Epitheliums Neurones (LIEN), University of Brest, 29200 Brest, France
C2 ANSES, FRANCE
   IFREMER, FRANCE
   IFREMER, FRANCE
   UNIV COTE D’AZUR, FRANCE
   MNHN, FRANCE
   INSERM, FRANCE
   ANSES, FRANCE
   UNIV ANGERS, FRANCE
   CEA, FRANCE
   UBO, FRANCE
SI SETE
   NANTES
SE PDG-ODE-LITTORAL-LERLR
   PDG-ODE-DYNECO-PHYC
UM MARBEC
IN WOS Ifremer UPR
   WOS Ifremer UMR
   DOAJ
   copubli-france
   copubli-univ-france
IF 6.085
TC 12
UR https://archimer.ifremer.fr/doc/00722/83432/88426.pdf
LA English
DT Article
DE ;brevetoxins;neurotoxic shellfish poisoning;shellfish;guidance level;marine biotoxins;emerging toxins
AB Brevetoxins (BTXs) are marine biotoxins responsible for neurotoxic shellfish poisoning (NSP) after ingestion of contaminated shellfish. NSP is characterized by neurological, gastrointestinal and/or cardiovascular symptoms. The main known producer of BTXs is the dinoflagellate Karenia brevis, but other microalgae are also suspected to synthesize BTX-like compounds. BTXs are currently not regulated in France and in Europe. In November 2018, they have been detected for the first time in France in mussels from a lagoon in the Corsica Island (Mediterranean Sea), as part of the network for monitoring the emergence of marine biotoxins in shellfish. To prevent health risks associated with the consumption of shellfish contaminated with BTXs in France, a working group was set up by the French Agency for Food, Environmental and Occupational Health & Safety (Anses). One of the aims of this working group was to propose a guidance level for the presence of BTXs in shellfish. Toxicological data were too limited to derive an acute oral reference dose (ARfD). Based on human case reports, we identified two lowest-observed-adverse-effect levels (LOAELs). A guidance level of 180 µg BTX-3 eq./kg shellfish meat is proposed, considering a protective default portion size of 400 g shellfish meat. 
PY 2021
PD SEP
SO Marine Drugs
SN 1660-3397
PU MDPI AG
VL 19
IS 9
UT 000700226400001
DI 10.3390/md19090520
ID 83432
ER

EF