FN Archimer Export Format
PT J
TI Rapid evolutionary turnover of mobile genetic elements drives bacterial resistance to phages
BT 
AF Hussain, Fatima Aysha
   Dubert, Javier
   Elsherbini, Joseph
   Murphy, Mikayla
   VanInsberghe, David
   Arevalo, Philip
   Kauffman, Kathryn
   Rodino-Janeiro, Bruno Kotska
   Gavin, Hannah
   Gomez, Annika
   Lopatina, Anna
   LE ROUX, Frederique
   Polz, Martin F.
AS 1:1;2:1,2;3:1;4:1;5:1;6:1;7:1;8:1,3;9:1;10:1;11:3;12:4,5;13:1,3;
FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;11:;12:PDG-RBE-PFOM;13:;
C1 Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
   Department of Microbiology and Parasitology, University of Santiago de Compostela, Santiago de Compostela, Spain.
   Division of Microbial Ecology, Department of Microbiology and Ecosystem Science, Center for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.
   Ifremer, Unité Physiologie Fonctionnelle des Organismes Marins, CS 10070, F-29280 Plouzané, France.
   Sorbonne Universités, UPMC Paris 06, CNRS, UMR 8227, Integrative Biology of Marine Models, Station Biologique de Roscoff, CS 90074, F-29688 Roscoff Cedex, France.
C2 MIT, USA
   UNIV SANTIAGO DE COMPOSTELA, SPAIN
   UNIV VIENNA, AUSTRIA
   IFREMER, FRANCE
   UNIV SORBONNE, FRANCE
SI ROSCOFF
SE PDG-RBE-PFOM
IN WOS Ifremer UPR
   copubli-france
   copubli-europe
   copubli-univ-france
   copubli-int-hors-europe
IF 63.832
TC 64
UR https://archimer.ifremer.fr/doc/00732/84375/89470.pdf
LA English
DT Article
AB Although it is generally accepted that phages drive bacterial evolution, how these dynamics play out in the wild remains poorly understood. We found that susceptibility to viral killing in marine Vibrio is mediated by large and highly diverse mobile genetic elements. These phage defense elements display exceedingly fast evolutionary turnover, resulting in differential phage susceptibility among clonal bacterial strains while phage receptors remain invariant. Protection is cumulative, and a single bacterial genome can harbor 6 to 12 defense elements, accounting for more than 90% of the flexible genome among close relatives. The rapid turnover of these elements decouples phage resistance from other genomic features. Thus, resistance to phages in the wild follows evolutionary trajectories alternative to those predicted from laboratory-based evolutionary experiments. 
PY 2021
PD OCT
SO Science
SN 0036-8075
PU American Association for the Advancement of Science (AAAS)
VL 374
IS 6566
UT 000710251800048
BP 488
EP 492
DI 10.1126/science.abb1083
ID 84375
ER

EF