FN Archimer Export Format
PT J
TI Chemodiversity of Brevetoxins and Other Potentially Toxic Metabolites Produced by Karenia spp. and Their Metabolic Products in Marine Organisms
BT 
AF Hort, Vincent
   ABADIE, Eric
   Arnich, Nathalie
   Dechraoui Bottein, Marie‐Yasmine
   AMZIL, Zouher
AS 1:1;2:2;3:3;4:4,5;5:6;
FF 1:;2:PDG-ODE-LITTORAL-LERLR;3:;4:;5:PDG-ODE-DYNECO-PHYC;
C1 Laboratory for Food Safety, Pesticides and Marine Biotoxins Unit, ANSES (French Agency for Food, Environmental and Occupational Health and Safety), 94701 Maisons-Alfort, France
   MARBEC (MARine Biodiversity, Exploitation and Conservation), Université de Montpellier, CNRS, Ifremer, IRD, 34200 Sète, France
   Risk Assessment Directorate, ANSES (French Agency for Food, Environmental and Occupational Health and Safety), 94701 Maisons-Alfort, France
   Université Côte d’Azur, CNRS, UMR 7035 ECOSEAS, 06103 Nice, France
   Federative Research Institute—Marine Ressources, Université Côte d’Azur, CNRS, 06108 Nice, France
   Ifremer (French Research Institute for Exploitation of the Sea), 44311 Nantes, France
C2 ANSES, FRANCE
   IFREMER, FRANCE
   ANSES, FRANCE
   UNIV COTE D’AZUR, FRANCE
   UNIV NICE, FRANCE
   IFREMER, FRANCE
SI SETE
   NANTES
SE PDG-ODE-LITTORAL-LERLR
   PDG-ODE-DYNECO-PHYC
UM MARBEC
IN WOS Ifremer UPR
   WOS Ifremer UMR
   DOAJ
   copubli-france
   copubli-univ-france
IF 6.085
TC 13
UR https://archimer.ifremer.fr/doc/00735/84730/89777.pdf
LA English
DT Article
DE ;Karenia spp;marine biotoxins;brevetoxins;metabolic products;shellfish;marine organisms
AB In recent decades, more than 130 potentially toxic metabolites originating from dinoflagellate species belonging to the genus Karenia or metabolized by marine organisms have been described. These metabolites include the well-known and large group of brevetoxins (BTXs), responsible for foodborne neurotoxic shellfish poisoning (NSP) and airborne respiratory symptoms in humans. Karenia spp. also produce brevenal, brevisamide and metabolites belonging to the hemi-brevetoxin, brevisin, tamulamide, gymnocin, gymnodimine, brevisulcenal and brevisulcatic acid groups. In this review, we summarize the available knowledge in the literature since 1977 on these various identified metabolites, whether they are produced directly by the producer organisms or biotransformed in marine organisms. Their structures and physicochemical properties are presented and discussed. Among future avenues of research, we highlight the need for more toxin occurrence data with analytical techniques, which can specifically determine the analogs present in samples. New metabolites have yet to be fully described, especially the groups of metabolites discovered in the last two decades (e.g tamulamides). Lastly, this work clarifies the different nomenclatures used in the literature and should help to harmonize practices in the future 
PY 2021
PD DEC
SO Marine Drugs
SN 1660-3397
PU MDPI AG
VL 19
IS 12
UT 000738241600001
DI 10.3390/md19120656
ID 84730
ER

EF