FN Archimer Export Format
PT J
TI Sulfo-Gambierones, Two New Analogs of Gambierone Produced by Gambierdiscus excentricus
BT 
AF YON, Thomas
   SIBAT, Manoella
   ROBERT, Elise
   LHAUTE, Korian
   Holland, Wiliam C
   LITAKER, R Wayne
   Bertrand, Samuel
   HESS, Philipp
   REVEILLON, Damien
AS 1:1;2:1;3:1;4:1;5:2;6:3;7:4,5;8:1;9:1;
FF 1:PDG-ODE-DYNECO-PHYC;2:PDG-ODE-DYNECO-PHYC;3:PDG-RBE-BRM-LPBA;4:PDG-ODE-DYNECO-PHYC;5:;6:;7:;8:PDG-ODE-DYNECO-PHYC;9:PDG-ODE-DYNECO-PHYC;
C1 Laboratoire Phycotoxines, DYNECO, Ifremer, F-44000 Nantes, France
   Beaufort Laboratory, National Centers for Coastal Ocean Science, National Ocean Service, NOAA, Beaufort, NC 28516, USA
   CSS, Inc. Under Contract to National Oceanic and Atmospheric Administration, National Centers for Coastal Ocean Science, National Ocean Service, Beaufort, NC 28516, USA
   Institut des Substances et Organismes de la Mer, ISOMER, Nantes Université, UR 2160, F-44000 Nantes, France
   ThalassOMICS Metabolomics Facility, Plateforme Corsaire, Biogenouest, 44311 Nantes, France
C2 IFREMER, FRANCE
   NOAA, USA
   CSS, USA
   UNIV NANTES, FRANCE
   THALASSOMICS, FRANCE
SI NANTES
SE PDG-ODE-DYNECO-PHYC
   PDG-RBE-BRM-LPBA
IN WOS Ifremer UPR
   DOAJ
   copubli-france
   copubli-univ-france
   copubli-int-hors-europe
IF 6.085
TC 13
UR https://archimer.ifremer.fr/doc/00735/84732/89778.pdf
   https://archimer.ifremer.fr/doc/00735/84732/89779.zip
LA English
DT Article
DE ;Gambierdiscus excentricus;sulfo-gambierones;high-resolution mass spectrometry;Neuro2a cell-based assay
AB Ciguatera poisoning is caused by the ingestion of fish or shellfish contaminated with ciguatoxins produced by dinoflagellate species belonging to the genera Gambierdiscus and Fukuyoa. Unlike in the Pacific region, the species producing ciguatoxins in the Atlantic Ocean have yet to be definitely identified, though some ciguatoxins responsible for ciguatera have been reported from fish. Previous studies investigating the ciguatoxin-like toxicity of Atlantic Gambierdiscus species using Neuro2a cell-based assay identified G. excentricus as a potential toxin producer. To more rigorously characterize the toxin profile produced by this species, a purified extract from 124 million cells was prepared and partial characterization by high-resolution mass spectrometry was performed. The analysis revealed two new analogs of the polyether gambierone: sulfo-gambierone and dihydro-sulfo-gambierone. Algal ciguatoxins were not identified. The very low ciguatoxin-like toxicity of the two new analogs obtained by the Neuro2a cell-based assay suggests they are not responsible for the relatively high toxicity previously observed when using fractionated G. excentricus extracts, and are unlikely the cause of ciguatera in the region. These compounds, however, can be useful as biomarkers of the presence of G. excentricus due to their sensitive detection by mass spectrometry 
PY 2021
PD DEC
SO Marine Drugs
SN 1660-3397
PU MDPI AG
VL 19
IS 12
UT 000738185800001
DI 10.3390/md19120657
ID 84732
ER

EF