FN Archimer Export Format
PT J
TI Epigenetics and the city: non‐parallel DNA methylation modifications across pairs of urban‐rural Great tit populations.
BT 
AF Caizergues, Aude E
   Le Luyer, Jeremy
   Grégoire, Arnaud
   Szulkin, Marta
   Senar, Juan‐Carlos
   Charmantier, Anne
   Perrier, Charles
AS 1:1;2:2;3:1;4:3;5:4;6:1;7:5;
FF 1:;2:PDG-RBE-RMPF;3:;4:;5:;6:;7:;
C1 CEFE Univ Montpellier CNRS EPHE, IRD Montpellier, France
   Ifremer, IRD, Institut Louis‐Malardé, Univ Polynésie Française, EIO Taravao, Tahiti Polynésie, Française
   Centre of New Technologies, University of Warsaw S. Banacha 2c 02‐097 Warsaw, Poland
   Museu de Ciències Naturals de Barcelona, Parc Ciutadella 08003 Barcelona ,Spain
   CBGP ,INRAe CIRAD, IRD, Montpellier SupAgro Univ. Montpellier Montpellier, France
C2 CNRS, FRANCE
   IFREMER, FRANCE
   UNIV WARSAW, POLAND
   MUSEU CIENCIES NATURALS BARCELONA, SPAIN
   INRAE, FRANCE
SI TAHITI
SE PDG-RBE-RMPF
UM EIO
IN WOS Ifremer UMR
   DOAJ
   copubli-france
   copubli-p187
   copubli-europe
IF 4.1
TC 14
UR https://archimer.ifremer.fr/doc/00740/85191/90195.pdf
   https://archimer.ifremer.fr/doc/00740/85191/90196.docx
LA English
DT Article
DE ;adaptation;DNA methylation;epigenomics;genomics;urbanization
AB Identifying the molecular mechanisms involved in rapid adaptation to novel environments and determining their predictability, are central questions in evolutionary biology and pressing issues due to rapid global changes. Complementary to genetic responses to selection, faster epigenetic variations such as modifications of DNA methylation may play a substantial role in rapid adaptation. In the context of rampant urbanization, joint examinations of genomic and epigenomic mechanisms are still lacking. Here, we investigated genomic (SNP) and epigenomic (CpG methylation) responses to urban life in a passerine bird, the Great tit (Parus major). To test whether urban evolution is predictable (i.e parallel) or involves mostly non-parallel molecular processes among cities, we analysed both SNP and CpG methylation variations across three distinct pairs of city and forest Great tit populations in Europe. Our analyses reveal a polygenic response to urban life, with both many genes putatively under weak divergent selection and multiple differentially methylated regions (DMRs) between forest and city great tits. DMRs mainly overlapped transcription start sites and promotor regions, suggesting their importance in modulating gene expression. Both genomic and epigenomic outliers were found in genomic regions enriched for genes with biological functions related to the nervous system, immunity, or behavioural, hormonal and stress responses. Interestingly, comparisons across the three pairs of city-forest populations suggested little parallelism in both genetic and epigenetic responses. Our results confirm, at both the genetic and epigenetic levels, hypotheses of polygenic and largely non-parallel mechanisms of rapid adaptation in novel environments such as urbanized areas. 
PY 2022
PD JAN
SO Evolutionary Applications
SN 1752-4571
PU Wiley
VL 15
IS 1
UT 000737759900001
BP 149
EP 165
DI 10.1111/eva.13334
ID 85191
ER

EF