FN Archimer Export Format
PT J
TI Morphological and genomic characterisation of the Schistosoma hybrid infecting humans in Europe reveals admixture between Schistosoma haematobium and Schistosoma bovis
BT 
AF Kincaid-Smith, Julien
   Tracey, Alan
   de Carvalho Augusto, Ronaldo
   Bulla, Ingo
   Holroyd, Nancy
   Rognon, Anne
   Rey, Olivier
   Chaparro, Cristian
   Oleaga, Ana
   Mas-Coma, Santiago
   Allienne, Jean-François
   Grunau, Christoph
   Berriman, Matthew
   Boissier, Jérôme
   Toulza, Eve
AS 1:1,2;2:3;3:1;4:1,4,5;5:3;6:1;7:1;8:1;9:6;10:7;11:1;12:1;13:3;14:1;15:1;
FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;11:;12:;13:;14:;15:;
C1 IHPE, Univ Perpignan Via Domitia, CNRS, IFREMER, Univ Montpellier, Perpignan, France
   CBGP, IRD, CIRAD, INRAE, Institut Agro, Univ Montpellier, Montpellier, France
   Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom
   Institute for Mathematics and Informatics, University of Greifswald, Greifswald, Germany
   Department of Computer Science, ETH Zurich, Zurich, Switzerland
   Parasitology Laboratory, Instituto de Recursos Naturales y Agrobiologý´a de Salamanca (IRNASA, CSIC), Cordel de Merinas, Spain
   Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Burjassot, Valencia, Spain
C2 UNIV PERPIGNAN, FRANCE
   UNIV MONTPELLIER, FRANCE
   WELLCOME SANGER INST, UK
   UNIV GREIFSWALD, GERMANY
   ETH ZURICH, SWITZERLAND
   CSIC, SPAIN
   UNIV VALENCIA, SPAIN
UM IHPE
IN WOS Cotutelle UMR
   DOAJ
   copubli-france
   copubli-europe
   copubli-univ-france
   copubli-int-hors-europe
IF 4.781
TC 17
UR https://archimer.ifremer.fr/doc/00742/85359/90424.pdf
   https://archimer.ifremer.fr/doc/00742/85359/90425.xlsx
LA English
DT Article
AB Schistosomes cause schistosomiasis, the world’s second most important parasitic disease after malaria in terms of public health and social-economic impacts. A peculiar feature of these dioecious parasites is their ability to produce viable and fertile hybrid offspring. Originally only present in the tropics, schistosomiasis is now also endemic in southern Europe. Based on the analysis of two genetic markers the European schistosomes had previously been identified as hybrids between the livestock- and the human-infective species Schistosoma bovis and Schistosoma haematobium, respectively. Here, using PacBio long-read sequencing technology we performed genome assembly improvement and annotation of S. bovis, one of the parental species for which no satisfactory genome assembly was available. We then describe the whole genome introgression levels of the hybrid schistosomes, their morphometric parameters (eggs and adult worms) and their compatibility with two European snail strains used as vectors (Bulinus truncatus and Planorbarius metidjensis). Schistosome-snail compatibility is a key parameter for the parasites life cycle progression, and thus the capability of the parasite to establish in a given area. Our results show that this Schistosoma hybrid is strongly introgressed genetically, composed of 77% S. haematobium and 23% S. bovis origin. This genomic admixture suggests an ancient hybridization event and subsequent backcrosses with the human-specific species, S. haematobium, before its introduction in Corsica. We also show that egg morphology (commonly used as a species diagnostic) does not allow for accurate hybrid identification while genetic tests do. 
PY 2021
PD DEC
SO PLOS Neglected Tropical Diseases
SN 1935-2735
PU Public Library of Science (PLoS)
VL 15
IS 12
UT 000733894300001
DI 10.1371/journal.pntd.0010062
ID 85359
ER

EF