FN Archimer Export Format
PT J
TI Cranberry and Sumac Extracts Exhibit Antibacterial and Anti-Adhesive Effects Against Streptococcus pyogenes
BT 
AF Abachi, Soheila
   Macé, Sabrina
   Lee, Song
   Rupasinghe, H.P. Vasantha
AS 1:1;2:2;3:3;4:1,4;
FF 1:;2:;3:;4:;
C1 Department of Plant, Food, and Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, Nova Scotia, Canada.
   IFREMER, BRM, EM3B Laboratory, Nantes, CEDEX 3, France.
   Department of Applied Oral Sciences, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia, Canada.
   Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
C2 UNIV DALHOUSIE, CANADA
   IFREMER, BRM, EM3B Laboratory, Nantes, CEDEX 3, France.
   UNIV DALHOUSIE, CANADA
   UNIV DALHOUSIE, CANADA
IF 2.4
TC 1
UR https://archimer.ifremer.fr/doc/00748/86014/96018.pdf
LA English
DT Article
DE ;adherence;antibacterial;bioactivity;pharyngitis;phytochemical;Streptococcus pyogenes
AB Group A Streptococci (GAS) or Streptococcus pyogenes is responsible for acute bacterial pharyngitis in children as well as adults. Streptococcal pharyngitis is initiated by successful attachment and colonization of the bacteria, followed by the establishment of the biofilm in various environments. In this study, we examined the antibacterial activities of in-house prepared aqueous and ethanolic extracts of 10 Atlantic Canada fruits in the context of minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), time–kill kinetics, and adhesion inhibition properties against S. pyogenes. Per our findings, MIC and MBC for all the tested extracts ranged from 0.25 to 8 mg/mL and from 4 to 64 mg/mL, respectively. Accordingly, at 1⁄2 × MBC, cranberry and sumac extracts also lowered the attachment of GAS to the uncoated and fibronectin-coated substratum. Particularly, cranberry and sumac aqueous extracts were more effective against the adhesion of S. pyogenes ATCC 19615 to the fibronectin-coated surface than a clinical strain. In conclusion, ethanolic and aqueous extracts of cranberry and sumac could potentially be incorporated into natural health products designed for the amelioration of strep throat, yet a detailed understanding of its mode of action (e.g., biofilm inhibition and eradication) could pave its path to the field of antibacterial natural health product discovery, design, and development. 
PY 2022
PD APR
SO Journal Of Medicinal Food
SN 1096-620X
PU Mary Ann Liebert Inc
VL 25
IS 4
UT 000758767400001
BP 426
EP 434
DI 10.1089/jmf.2021.0047
ID 86014
ER

EF