FN Archimer Export Format
PT J
TI Human poisonings by neurotoxic phycotoxins related to the consumption of shellfish: study of cases registered by the French Poison Control Centres from 2012 to 2019
BT 
AF Sinno-Tellier, Sandra
   Abadie, Eric
   de Haro, Luc
   Paret, Nathalie
   Langrand, Jérôme
   Le Roux, Gaël
   Labadie, Magali
   Boels, David
   Bloch, Juliette
   Delcourt, Nicolas
AS 1:1;2:2;3:3;4:4;5:5;6:6;7:7;8:8;9:1;10:9;
FF 1:;2:PDG-ODE-LITTORAL-LERLR;3:;4:;5:;6:;7:;8:;9:;10:;
C1 French Agency for Food, Environmental and Occupational Health and Safety, Maisons-Alfort, France
   French Research Institute for Exploitation of the Sea, Sète, France
   Poison Control Centre, Marseille University Hospital, Marseille, France
   Poison Control Centre, Lyon University Hospital, Lyon, France
   Poison Control Centre, Paris University Hospital, Paris, France
   Poison Control Centre, Angers University Hospital, Angers, France
   Poison Control Centre, Bordeaux University Hospital, Bordeaux, France
   Pharmacology and Toxicology Department, Nantes University Hospital, Nantes, France
   Poison Control Centre, Toulouse University Hospital, Toulouse, France
C2 ANSES, FRANCE
   IFREMER, FRANCE
   CHU MARSEILLE, FRANCE
   CHU LYON, FRANCE
   CHU PARIS, FRANCE
   CHU ANGERS, FRANCE
   CHU BORDEAUX, FRANCE
   CHU NANTES, FRANCE
   CHU TOULOUSE, FRANCE
SI SETE
SE PDG-ODE-LITTORAL-LERLR
UM MARBEC
IN WOS Ifremer UMR
   copubli-france
IF 3.3
TC 4
UR https://archimer.ifremer.fr/doc/00750/86204/96013.pdf
LA English
DT Article
DE ;Phycotoxins;poison control centre;shellfish;saxitoxin;epidemiology
AB Context In June 2019, a paralytic shellfish poisoning (PSP) case related to the consumption of mussels contaminated by saxitoxins at a concentration below the regulatory threshold came to the attention of the French Agency for Food, Environmental and Occupational Health and Safety (ANSES). This pointed to probable undetected human cases of poisoning by neurotoxic phycotoxins. Methods We conducted a retrospective study of poisoning cases by bivalve shellfish (oysters, mussels and scallops) recorded by the French Poison Control Centres (PCC) from 2012 to 2019. All medical records were reviewed by a toxicologist. Cases that could be related to neurotoxic phycotoxins were selected and described. Diagnosis was based on symptoms compatible with ingestion of contaminated shellfish and on contamination data for the shellfish production area (analysed by the French Research Institute for Exploitation of the Sea, Ifremer), or notifications to the European Rapid Alert System for Food and Feed when the origin of the shellfish was known. Results Among the 619 shellfish poisoning cases recorded by the PCCs from 2012 to 2019, 22% (n = 134) had reported at least one neurological symptom (headache, dizziness or paraesthesia). Review of medical records for the 134 patients led to suspicion of 14 cases of PSP and one case of amnesic shellfish poisoning. Five patients experienced persistent neurological symptoms. Marine toxins were not tested for in the blood or urine of these patients. Conclusion This retrospective identification of cases strongly suspected of being related to neurotoxic phycotoxins led ANSES, PCCs and Ifremer to develop a specific questionnaire and to recommend actions to take when neurological symptoms related to shellfish consumption are reported to a PCC. Daily monitoring of shellfish poisoning cases registered in the national PCCs database was also implemented in order to rapidly detect any suspicious cases, alert the competent authorities, and warn the general population. 
PY 2022
PD JUL
SO Clinical Toxicology
SN 1556-3650
PU Informa UK Limited
VL 60
IS 6
UT 000753908900001
BP 759
EP 767
DI 10.1080/15563650.2022.2034840
ID 86204
ER

EF