FN Archimer Export Format
PT J
TI Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection
BT 
AF Fallet, Manon
   Montagnani, Caroline
   Petton, Bruno
   Dantan, Luc
   DE LORGERIL, Julien
   Comarmond, Sébastien
   Chaparro, Cristian
   Toulza, Eve
   Boitard, Simon
   Escoubas, Jean Michel
   Vergnes, Agnes
   LE GRAND, Jacqueline
   Bulla, Ingo
   Gueguen, Yannick
   Vidal-Dupiol, Jeremie
   Grunau, Christoph
   Mitta, Guillaume
   COSSAU, Céline
AS 1:7;2:1;3:2;4:7;5:1,3;6:7;7:7;8:7;9:4;10:8;11:1;12:2;13:7;14:1,5;15:1;16:7;17:6,7;18:7;
FF 1:;2:PDG-RBE-IHPE;3:PDG-RBE-PFOM-LPI;4:;5:PDG-RBE-LEADNC;6:;7:;8:;9:;10:;11:PDG-RBE-IHPE;12:PDG-RBE-PFOM-LPI;13:;14:PDG-ODE-LITTORAL-LERLR;15:PDG-RBE-IHPE;16:;17:PDG-RBE-RMPF;18:;
C1 IHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France
   Ifremer, UBO CNRS IRD, LEMAR UMR 6539, Argenton, France
   Ifremer, IRD, Univ Nouvelle-Calédonie, Univ La Réunion, ENTROPIE, F-98800, Nouméa, Nouvelle-Calédonie, France
   CBGP, CIRAD, INRAE, Institut Agro, IRD, Université de Montpellier, Montpellier, France
   MARBEC, CNRS, Ifremer, IRD, Univ Montpellier, Sète, France
   Ifremer, UMR 241 Écosystèmes Insulaires Océaniens, Labex Corail, Centre Ifremer du Pacifique, BP 49, 98725, Tahiti, French Polynesia
   IHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France
   IHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France
C2 IFREMER, FRANCE
   IFREMER, FRANCE
   IFREMER, FRANCE
   UNIV MONTPELLIER, FRANCE
   IFREMER, FRANCE
   IFREMER, FRANCE
   UNIV PERPIGNAN, FRANCE
   CNRS, FRANCE
SI MONTPELLIER
   ARGENTON
   SAINT VINCENT
   BREST
   SETE
   TAHITI
SE PDG-RBE-IHPE
   PDG-RBE-PFOM-LPI
   PDG-RBE-LEADNC
   PDG-ODE-LITTORAL-LERLR
   PDG-RBE-RMPF
UM LEMAR
   MARBEC
   IHPE
   EIO
   ENTROPIE
IN WOS Ifremer UMR
   WOS Cotutelle UMR
   DOAJ
   copubli-france
   copubli-univ-france
IF 15.5
TC 19
UR https://archimer.ifremer.fr/doc/00753/86457/91789.docx
   https://archimer.ifremer.fr/doc/00753/86457/91790.xlsx
   https://archimer.ifremer.fr/doc/00753/86457/91791.docx
   https://archimer.ifremer.fr/doc/00753/86457/91793.xlsx
   https://archimer.ifremer.fr/doc/00753/86457/91794.xlsx
   https://archimer.ifremer.fr/doc/00753/86457/91795.xlsx
   https://archimer.ifremer.fr/doc/00753/86457/91796.xlsx
   https://archimer.ifremer.fr/doc/00753/86457/91797.xlsx
   https://archimer.ifremer.fr/doc/00753/86457/91798.xlsx
   https://archimer.ifremer.fr/doc/00753/86457/91799.xlsx
   https://archimer.ifremer.fr/doc/00753/86457/91800.xlsx
   https://archimer.ifremer.fr/doc/00753/86457/94478.pdf
LA English
DT Article
DE ;Oyster;Aquaculture;Microbiota;Innate immune shaping;Epigenetic;DNA methylation
AB Background The interaction of organisms with their surrounding microbial communities influences many biological processes, a notable example of which is the shaping of the immune system in early life. In the Pacific oyster, Crassostrea gigas, the role of the environmental microbial community on immune system maturation – and, importantly, protection from infectious disease – is still an open question. Results Here, we demonstrate that early life microbial exposure durably improves oyster survival when challenged with the pathogen causing Pacific Oyster Mortality Syndrome (POMS), both in the exposed generation and in the subsequent one. Combining microbiota, transcriptomic, genetic, and epigenetic analyses, we show that the microbial exposure induced changes in epigenetic marks and a reprogramming of immune gene expression leading to long-term and intergenerational immune protection against POMS. Conclusions We anticipate that this protection likely extends to additional pathogens and may prove to be an important new strategy for safeguarding oyster aquaculture efforts from infectious disease. 
PY 2022
PD JUL
SO Microbiome
SN 2049-2618
PU BMC
VL 10
IS 1
UT 000805942700001
DI 10.1186/s40168-022-01280-5
ID 86457
ER

EF