FN Archimer Export Format PT J TI Fucoxanthin from Algae to Human, an Extraordinary BioreSource: Insights and Advances in up and Downstream Processes BT AF Pajot, Anne Hao Huynh, Gia Picot, Laurent Marchal, Luc Nicolau, Elodie AS 1:1;2:1;3:2;4:3;5:1; FF 1:PDG-ODE-PHYTOX-GENALG;2:;3:;4:;5:PDG-ODE-PHYTOX-GENALG; C1 Ifremer, GENALG Laboratory, Unité PHYTOX, F-44000 Nantes, France Unité Mixte de Recherche CNRS 7266 Littoral Environnement et Sociétés (LIENSs), Université La Rochelle, F-17042 La Rochelle, France Génie des Procédés Environnement (GEPEA), Université Nantes, F-44000 Saint Nazaire, France C2 IFREMER, FRANCE UNIV LA ROCHELLE, FRANCE UNIV NANTES, FRANCE SI NANTES SE PDG-ODE-PHYTOX-GENALG IN WOS Ifremer UPR DOAJ copubli-france copubli-univ-france IF 5.4 TC 34 UR https://archimer.ifremer.fr/doc/00761/87280/92816.pdf LA English DT Article DE ;fucoxanthin;golden-brown algae;Tisochrysis lutea;biosynthesis;downstream processes;extraction;centrifugal partition chromatography;global market AB Fucoxanthin is a brown-colored pigment from algae, with great potential as a bioactive molecule due to its numerous properties. This review aims to present current knowledge on this high added-value pigment. An accurate analysis of the biological function of fucoxanthin explains its wide photon absorption capacities in golden-brown algae. The specific chemical structure of this pigment also leads to many functional activities in human health. They are outlined in this work and are supported by the latest studies in the literature. The scientific and industrial interest in fucoxanthin is correlated with great improvements in the development of algae cultures and downstream processes. The best fucoxanthin producing algae and their associated culture parameters are described. The light intensity is a major influencing factor, as it has to enable both a high biomass growth and a high fucoxanthin content. This review also insists on the most eco-friendly and innovative extraction methods and their perspective within the next years. The use of bio-based solvents, aqueous two-phase systems and the centrifugal partition chromatography are the most promising processes. The analysis of the global market and multiple applications of fucoxanthin revealed that Asian companies are major actors in the market with macroalgae. In addition, fucoxanthin from microalgae are currently produced in Israel and France, and are mostly authorized in the USA PY 2022 PD APR SO Marine Drugs SN 1660-3397 PU MDPI AG VL 20 IS 4 UT 000785111300001 DI 10.3390/md20040222 ID 87280 ER EF