FN Archimer Export Format
PT J
TI The retinal ganglion cell layer reflects neurodegenerative changes in cognitively unimpaired individuals
BT 
AF López-de-Eguileta, Alicia
   López-García, Sara
   Lage, Carmen
   Pozueta, Ana
   García-Martínez, María
   Kazimierczak, Martha
   Bravo, María
   Irure, Juan
   López-Hoyos, Marcos
   Muñoz-Cacho, Pedro
   Rodríguez-Perez, Noelia
   Tordesillas-Gutiérrez, Diana
   Goikoetxea, Alexander
   Nebot, Claudia
   Rodríguez-Rodríguez, Eloy
   Casado, Alfonso
   Sánchez-Juan, Pascual
AS 1:1;2:2;3:2;4:2;5:2;6:2;7:2;8:3;9:;10:4;11:2,5;12:5;13:6;14:1;15:;16:1;17:2;
FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;11:;12:;13:;14:;15:;16:;17:;
C1 Department of Ophthalmology, ‘Marqués de Valdecilla’ University Hospital, Institute for Research ‘Marqués de Valdecilla’ Santander, University of Cantabria, Santander, Spain
   Cognitive Impairment Unit, Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), ‘Marqués de Valdecilla’ University Hospital, Institute for Research ‘Marqués de Valdecilla’ (IDIVAL), University of Cantabria, Santander, Spain
   Department of Immunology, ‘Marqués de Valdecilla’ University Hospital of Cantabria, Institute for Research ‘Marqués de Valdecilla’, Santander, Spain
   Department of Medicina Familiar y Comunitaria, IDIVAL, Santander, Spain
   Valdecilla Biomedical Research Institute (IDIVAL), Santander, Spain
   MARBEC Univ Montpellier, CNRS, Ifremer, IRD, Palavas-les-Flots, France
C2 UNIV CANTABRIA, SPAIN
   UNIV CANTABRIA, SPAIN
   UNIV CANTABRIA, SPAIN
   IDIVAL, SPAIN
   IDIVAL, SPAIN
   MARBEC Univ Montpellier, CNRS, Ifremer, IRD, Palavas-les-Flots, France
IN DOAJ
IF 9
TC 6
UR https://archimer.ifremer.fr/doc/00766/87850/93431.pdf
   https://archimer.ifremer.fr/doc/00766/87850/93432.docx
LA English
DT Article
DE ;Alzheimer's disease;Optical coherence tomography;Amyloid;Tau;Ganglion cell layer;Retinal nerve fiber layer;Neurodegeneration;Hippocampal volume
AB Background To evaluate a wide range of optical coherence tomography (OCT) parameters for possible application as a screening tool for cognitively healthy individuals at risk of Alzheimer’s disease (AD), assessing the potential relationship with established cerebrospinal fluid (CSF) core AD biomarkers and magnetic resonance imaging (MRI). Methods We studied 99 participants from the Valdecilla Study for Memory and Brain Aging. This is a prospective cohort for multimodal biomarker discovery and validation that includes participants older than 55 years without dementia. Participants received a comprehensive neuropsychological battery and underwent structural 3-T brain MRI, lumbar puncture for CSF biomarkers (phosphorylated-181-Tau (pTau), total Tau (tTau), beta-amyloid 1–42 (Aβ 1–42), and beta-amyloid 1–40 (Aβ 1–40)). All individuals underwent OCT to measure the retinal ganglion cell layer (GCL), the retinal nerve fiber layer (RFNL), the Bruch’s membrane opening-minimum rim width (BMO-MRW), and choroidal thickness (CT). In the first stage, we performed a univariate analysis, using Student’s t-test. In the second stage, we performed a multivariate analysis including only those OCT parameters that discriminated at a nominal level, between positive/negative biomarkers in stage 1. Results We found significant differences between the OCT measurements of pTau- and tTau-positive individuals compared with those who were negative for these markers, most notably that the GCL and the RNFL were thinner in the former. In stage 2, our dependent variables were the quantitative values of CSF markers and the hippocampal volume. The Aβ 1–42/40 ratio did not show a significant correlation with OCT measurements while the associations between pTau and tTau with GCL were statistically significant, especially in the temporal region of the macula. Besides, the multivariate analysis showed a significant correlation between hippocampal volume with GCL and RNFL. However, after false discovery rate correction, only the associations with hippocampal volume remained significant. Conclusions We found a significant correlation between Tau (pTau) and neurodegeneration biomarkers (tTau and hippocampus volume) with GCL degeneration and, to a lesser degree, with damage in RFNL. OCT analysis constitutes a non-invasive and unexpensive biomarker that allows the detection of neurodegeneration in cognitively asymptomatic individuals. 
PY 2022
PD APR
SO Alzheimers Research & Therapy
SN 1758-9193
PU Springer Science and Business Media LLC
VL 14
IS 1
UT 000784575800001
DI 10.1186/s13195-022-00998-6
ID 87850
ER

EF