FN Archimer Export Format
PT J
TI Dissemination of Extended-Spectrum-β-Lactamase-Producing Enterobacter cloacae Complex from a Hospital to the Nearby Environment in Guadeloupe (French West Indies): ST114 Lineage Coding for a Successful IncHI2/ST1 Plasmid
BT 
AF POT, Matthieu
   GUYOMARD-RABENIRINA, Stephanie
   COUVIN, David
   DUCAT, Celia
   ENOUF, Vincent
   FERDINAND, Severine
   GRUEL, Gaelle
   MALPOTE, Edith
   TALARMIN, Antoine
   BREUREC, Sebastien
   REYNAUD, Yann
AS 1:1;2:1;3:1;4:1;5:2;6:1;7:1;8:3;9:1;10:1,4,5;11:1;
FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;11:;
C1 Pasteur Inst Guadeloupe, Transmiss Reservoir & Divers Pathogens Unit, Les Abymes, France.
   Pasteur Inst Paris, Plateforme Microbiol Mutualisee P2M, Pasteur Int Bioresources Network PIBnet, Paris, France.
   Univ Hosp Guadeloupe, Lab Clin Microbiol, Pointe A Pitre, Guadeloupe, France.
   Univ Antilles, Fac Med Hyacinthe Bastaraud, Pointe A Pitre, Guadeloupe, France.
   INSERM, Ctr Clin Invest 1424, Pointe A Pitre, Guadeloupe, France.
C2 INST PASTEUR GUADELOUPE, FRANCE
   INST PASTEUR, FRANCE
   UNIV HOSP GUADELOUPE, FRANCE
   UNIV ANTILLES, FRANCE
   INSERM, FRANCE
IF 5.938
TC 10
UR https://archimer.ifremer.fr/doc/00771/88292/93843.pdf
   https://archimer.ifremer.fr/doc/00771/88292/93844.pdf
   https://archimer.ifremer.fr/doc/00771/88292/93845.xlsx
   https://archimer.ifremer.fr/doc/00771/88292/93846.xlsx
LA English
DT Article
DE ;Enterobacter cloacae complex;bla(CTX-M-15);IncHI2;one health;ST114;wastewater treatment plant;wildlife
AB Wastewater treatment plants are considered hot spots for antibiotic resistance. Most studies have addressed the impact on the aquatic environment, as water is an important source of anthropogenic pollutants. Few investigations have been conducted on terrestrial animals living near treatment ponds. We isolated extended-spectrum-beta-lactamase Enterobacter cloacae complex-producing strains from 35 clinical isolates, 29 samples of wastewater, 19 wild animals, and 10 domestic animals living in the hospital sewers and at or near a wastewater treatment plant to study the dissemination of clinically relevant resistance through hospital and urban effluents. After comparison of the antibiotic-resistant profiles of E. cloacae complex strains, a more detailed analysis of 41 whole-genome-sequenced strains demonstrated that the most common sequence type, ST114 (n =20), was present in human (n =9) and nonhuman (n = 11) samples, with a close genetic relatedness. Whole-genome sequencing confirmed local circulation of this pathogenic lineage in diverse animal species. In addition, nanopore sequencing and specific synteny of an IncHI2/ST1/bla(CTX-M-15), plasmid recovered on the majority of these ST114 clones (n =18) indicated successful worldwide diffusion of this mobile genetic element. 
PY 2021
PD MAR
SO Antimicrobial Agents And Chemotherapy
SN 0066-4804
PU Amer Soc Microbiology
VL 65
IS 3
UT 000619864100047
DI 10.1128/AAC.02146-20
ID 88292
ER

EF