TY - JOUR T1 - New Mycobacterium tuberculosis Beijing clonal complexes in China revealed by phylogenetic and Bayesian population structure analyses of 24-loci MIRU-VNTRs A1 - Zheng,Chao A1 - Reynaud,Yann A1 - Zhao,Changsong A1 - Zozio,Thierry A1 - Li,Song A1 - Luo,Dongxia A1 - Sun,Qun A1 - Rastogi,Nalin UR - https://archimer.ifremer.fr/doc/00771/88304/ DO - 10.1038/s41598-017-06346-1 N2 - Beijing lineage of Mycobacterium tuberculosis constitutes the most predominant lineage in East Asia. Beijing epidemiology, evolutionary history, genetics are studied in details for years revealing probable origin from China followed by worldwide expansion, partially linked to higher mutation rate, hypervirulence, drug-resistance, and association with cases of mixed infections. Considering huge amount of data available for 24-loci Mycobacterial Interspersed Repetitive Units-Variable Number of Tandem Repeats, we performed detailed phylogenetic and Bayesian population structure analyses of Beijing lineage strains in mainland China and Taiwan using available 24-loci MIRU-VNTR data extracted from publications or the SITVIT2 database (n = 1490). Results on genetic structuration were compared to previously published data. A total of three new Beijing clonal complexes tentatively named BSP1, BPS2 and BSP3 were revealed with surprising phylogeographical specificities to previously unstudied regions in Sichuan, Chongqing and Taiwan, proving the need for continued investigations with extended datasets. Such geographical restriction could correspond to local adaptation of these “ecological specialist” Beijing isolates to local human host populations in contrast with “generalist pathogens” able to adapt to several human populations and to spread worldwide. Y1 - 2017/12 PB - Springer Science and Business Media LLC JF - Scientific Reports SN - 2045-2322 VL - 7 IS - 1 ID - 88304 ER -