FN Archimer Export Format
PT J
TI New Mycobacterium tuberculosis Beijing clonal complexes in China revealed by phylogenetic and Bayesian population structure analyses of 24-loci MIRU-VNTRs
BT 
AF Zheng, Chao
   REYNAUD, Yann
   Zhao, Changsong
   Zozio, Thierry
   Li, Song
   Luo, Dongxia
   Sun, Qun
   Rastogi, Nalin
AS 1:;2:;3:;4:;5:;6:;7:;8:;
FF 1:;2:;3:;4:;5:;6:;7:;8:;
IN DOAJ
IF 4.122
TC 4
UR https://archimer.ifremer.fr/doc/00771/88304/93941.pdf
   https://archimer.ifremer.fr/doc/00771/88304/93942.pdf
LA English
DT Article
AB Beijing lineage of Mycobacterium tuberculosis constitutes the most predominant lineage in East Asia. Beijing epidemiology, evolutionary history, genetics are studied in details for years revealing probable origin from China followed by worldwide expansion, partially linked to higher mutation rate, hypervirulence, drug-resistance, and association with cases of mixed infections. Considering huge amount of data available for 24-loci Mycobacterial Interspersed Repetitive Units-Variable Number of Tandem Repeats, we performed detailed phylogenetic and Bayesian population structure analyses of Beijing lineage strains in mainland China and Taiwan using available 24-loci MIRU-VNTR data extracted from publications or the SITVIT2 database (n = 1490). Results on genetic structuration were compared to previously published data. A total of three new Beijing clonal complexes tentatively named BSP1, BPS2 and BSP3 were revealed with surprising phylogeographical specificities to previously unstudied regions in Sichuan, Chongqing and Taiwan, proving the need for continued investigations with extended datasets. Such geographical restriction could correspond to local adaptation of these “ecological specialist” Beijing isolates to local human host populations in contrast with “generalist pathogens” able to adapt to several human populations and to spread worldwide. 
PY 2017
PD DEC
SO Scientific Reports
SN 2045-2322
PU Springer Science and Business Media LLC
VL 7
IS 1
UT 000405907800119
DI 10.1038/s41598-017-06346-1
ID 88304
ER

EF