FN Archimer Export Format
PT J
TI The extensive transgenerational transcriptomic effects of ocean acidification on the olfactory epithelium of a marine fish are associated with a better viral resistance
BT 
AF COHEN-Rengifo, Mishal
   Danion, Morgane
   Gonzalez, Anne-Alicia
   Bégout, Marie-Laure
   Cormier, Alexandre
   Noël, Cyril
   Cabon, Joëlle
   Vitré, Thomas
   Mark, Felix C.
   Mazurais, David
AS 1:1;2:2;3:3;4:4;5:5;6:5;7:2;8:1;9:6;10:1;
FF 1:;2:;3:;4:PDG-RBE-MARBEC-LSEA;5:PDG-IRSI-SEBIMER;6:PDG-IRSI-SEBIMER;7:;8:;9:;10:PDG-RBE-PFOM-LARN;
C1 IFREMER, PFOM-ARN, 29280, Plouzané, France
   Ploufragan-Plouzané Laboratory, Fish Viral Pathology Unit, French Agency for Food, Environmental and Occupational Health and Safety (ANSES), Technopôle Brest-Iroise, 29280, Plouzané, France
   MGX, CNRS, INSERM, University of Montpellier, Biocampus Montpellier, Montpellier, France
   MARBEC, University of Montpellier, CNRS, IFREMER, 34250, Palavas-les-Flots, IRD, France
   IFREMER, SEBIMER, 29280, Plouzané, France
   Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research (AWI), Department of Integrative Ecophysiology, 27570, Bremerhaven, Germany
C2 IFREMER, FRANCE
   ANSES, FRANCE
   UNIV MONTPELLIER, FRANCE
   IFREMER, FRANCE
   IFREMER, FRANCE
   INST A WEGENER, GERMANY
SI BREST
   PALAVAS
SE PDG-RBE-PFOM-LARN
   PDG-RBE-MARBEC-LSEA
   PDG-IRSI-SEBIMER
UM LEMAR
   MARBEC
IN WOS Ifremer UPR
   WOS Ifremer UMR
   DOAJ
   copubli-france
   copubli-europe
   copubli-univ-france
IF 4.4
TC 5
UR https://archimer.ifremer.fr/doc/00777/88898/94499.pdf
   https://archimer.ifremer.fr/doc/00777/88898/94500.zip
   https://archimer.ifremer.fr/doc/00777/88898/102864.pdf
LA English
DT Article
DE ;Anti-viral immunity;Betanodavirus;Climate change;European sea bass;Long-term transgenerational ocean acidification;Metabolism;Neuro-sensory system;Olfactory epithelium;Transcriptomics
AB Abstract Background Progressive CO2-induced ocean acidification (OA) impacts marine life in ways that are difficult to predict but are likely to become exacerbated over generations. Although marine fishes can balance acid–base homeostasis efficiently, indirect ionic regulation that alter neurosensory systems can result in behavioural abnormalities. In marine invertebrates, OA can also affect immune system function, but whether this is the case in marine fishes is not fully understood. Farmed fish are highly susceptible to disease outbreak, yet strategies for overcoming such threats in the wake of OA are wanting. Here, we exposed two generations of the European sea bass (Dicentrarchus labrax) to end-of-century predicted pH levels (IPCC RCP8.5), with parents (F1) being exposed for four years and their offspring (F2) for 18 months. Our design included a transcriptomic analysis of the olfactory rosette (collected from the F2) and a viral challenge (exposing F2 to betanodavirus) where we assessed survival rates. Results We discovered transcriptomic trade-offs in both sensory and immune systems after long-term transgenerational exposure to OA. Specifically, RNA-Seq analysis of the olfactory rosette, the peripheral olfactory organ, from 18-months-old F2 revealed extensive regulation in genes involved in ion transport and neuronal signalling, including GABAergic signalling. We also detected OA-induced up-regulation of genes associated with odour transduction, synaptic plasticity, neuron excitability and wiring and down-regulation of genes involved in energy metabolism. Furthermore, OA-exposure induced up-regulation of genes involved in innate antiviral immunity (pathogen recognition receptors and interferon-stimulated genes) in combination with down-regulation of the protein biosynthetic machinery. Consistently, OA-exposed F2 challenged with betanodavirus, which causes damage to the nervous system of marine fish, had acquired improved resistance. Conclusion F2 exposed to long-term transgenerational OA acclimation showed superior viral resistance, though as their metabolic and odour transduction programs were altered, odour-mediated behaviours might be consequently impacted. Although it is difficult to unveil how long-term OA impacts propagated between generations, our results reveal that, across generations, trade-offs in plastic responses is a core feature of the olfactory epithelium transcriptome in OA-exposed F2 offspring, and will have important consequences for how cultured and wild fish interacts with its environment. 
PY 2022
PD JUL
SO Bmc Genomics
SN 1471-2164
PU Springer Science and Business Media LLC
VL 23
IS 1
UT 000812249800001
DI 10.1186/s12864-022-08647-w
ID 88898
ER

EF