FN Archimer Export Format
PT J
TI Mechanical relaxations of hydrogels governed by their physical or chemical crosslinks
BT 
AF Cuenot, Stéphane
   Gélébart, Perrine
   Sinquin, Corinne
   COLLIEC JOUAULT, Sylvia
   Zykwinska, Agata
AS 1:1;2:2;3:2;4:2;5:2;
FF 1:;2:PDG-RBE-MASAE-LEMMMB;3:PDG-RBE-MASAE-LEMMMB;4:PDG-RBE-MASAE-LEMMMB;5:PDG-RBE-MASAE-LEMMMB;
C1 Nantes Université, CNRS, Institut des Matériaux Jean Rouxel, IMN, 2, Rue de la Houssinière, 44322, Nantes, France
   Ifremer MASAE, 44300, Nantes, France
C2 UNIV NANTES, FRANCE
   IFREMER, FRANCE
SI NANTES
SE PDG-RBE-MASAE-LEMMMB
IN WOS Ifremer UPR
   copubli-france
   copubli-univ-france
IF 3.9
TC 11
UR https://archimer.ifremer.fr/doc/00780/89193/104034.pdf
LA English
DT Article
DE ;AFM;Viscoelasticity;Poroelasticity;Hydrogels;Infernan;Force relaxation
AB In the field of tissue engineering, in order to restore tissue functionality hydrogels that closely mimic biological and mechanical properties of the extracellular matrix are intensely developed. Mechanical properties including relaxation of the surrounding microenvironment regulate essential cellular processes. However, the mechanical properties of engineered hydrogels are particularly complex since they involve not only a nonlinear elastic behavior but also time-dependent responses. An accurate determination of these properties at microscale, i.e. as probed by cells, becomes an essential step to further design hydrogel-based biomaterials able to induce specific cellular responses. Atomic Force Microscopy (AFM) with contact sizes of the order of few micrometers constitutes an appropriate technique to determine the origin of relaxation mechanisms occurring in hydrogels. In the present study, AFM force relaxation experiments are conducted on chemically and physically crosslinked hydrogels respectively based on a synthetic polymer, polyacrylamide and a natural polymer, a bacterial exopolysaccharide infernan, produced by the deep-sea hydrothermal vent bacterium, Alteromonas infernus. Two distinct relaxation mechanisms are clearly evidenced depending on the nature of hydrogel network crosslinks. Chemically crosslinked hydrogel exhibits poroelastic relaxations, whereas physically crosslinked hydrogel shows time-dependent responses arising from viscoelastic effects. In addition, two relaxation processes are revealed in ionic physical hydrogel originating from chain rearrangement and breaking/reforming of the ionic crosslinks. The effect of the ionic strength on both the long-term elastic modulus and relaxation times of physical hydrogels was also shown. These findings highlight that physical hydrogels with well-defined time-dependent mechanical properties could be tuned for an optimized response of cells. 
PY 2022
PD SEP
SO Journal Of The Mechanical Behavior Of Biomedical Materials
SN 1751-6161
PU Elsevier BV
VL 133
UT 000841072400005
DI 10.1016/j.jmbbm.2022.105343
ID 89193
ER

EF