FN Archimer Export Format
PT J
TI Effects of 17α-Ethinylestradiol (EE2) exposure during early life development on the gonadotropic axis ontogenesis of the European sea bass, Dicentrarchus labrax
BT 
AF Soloperto, Sofia
   Nihoul, Florent
   Olivier, Stéphanie
   Poret, Agnès
   Couteau, Jérôme
   Halm-Lemeille, Marie-Pierre
   Danger, Jean-Michel
   Aroua, Salima
AS 1:1;2:1;3:1;4:1;5:2;6:3;7:1;8:1;
FF 1:;2:;3:;4:;5:;6:PDG-ODE-LITTORAL;7:;8:;
C1 UMR-I 02 INERIS-URCA-ULH SEBIO, Normandie Univ, UNIHAVRE, FR CNRS 3730 Scale, Le Havre, France
   SARL TOXEM, Montivilliers, France
   Laboratoire Environnement Ressources de Normandie, IFREMER, Port-en-Bessin, France
C2 UNIV LE HAVRE NORMANDIE, FRANCE
   SARL TOXEM, FRANCE
   IFREMER, FRANCE
SI PORT-EN-BESSIN
SE PDG-ODE-LITTORAL
IN WOS Ifremer UPR
   copubli-france
   copubli-univ-france
IF 2.3
TC 1
UR https://archimer.ifremer.fr/doc/00780/89205/94825.pdf
LA English
DT Article
DE ;Neuroendocrine disruption;Xenoestrogens;Gonadotropin-releasing hormones;Kisspeptins;Gonadotropins;Larva
AB Exposure of young organisms to oestrogenic endocrine disrupting chemicals (EDCs) can elicit adverse effects, particularly on the reproductive function. In fish, as in other vertebrates, reproduction is controlled by the neuroendocrine gonadotropic axis, whose components are mainly regulated by sex steroids and may then be targets for EDCs. In the present study, we investigated the effects of a xenoestrogen exposure on the ontogenesis of the gonadotropic axis in European sea bass. After exposure of hatching larvae for 8 days to 17α-ethinylestradiol (EE2) (0.5 nM and 50 nM), gene expression for kisspeptins (kiss1, kiss2), gonadotropin-releasing hormones (gnrh1, gnrh2, gnrh3), gonadotropin beta subunits (lhβ and fshβ) and brain type aromatase (cyp19a1b) were measured using quantitative real-time PCR. Our results demonstrate that EE2 strongly stimulated the expression of brain type aromatase (cyp19a1b) in sea bass larvae. In addition, EE2 exposure also affected the mRNA levels of kiss1, gnrh1 and gnrh3 by inducing a downregulation of these genes during the early developmental stages, while no effect was seen in gnrh2, lhβ and fshβ. These results reinforce the idea that the larval development is a sensitive critical period in regard to endocrine disruption and that the gonadotropic axis in the developing sea bass is sensitive to xenoestrogen exposure. 
PY 2022
PD SEP
SO Comparative Biochemistry And Physiology A-molecular & Integrative Physiology
SN 1095-6433
PU Elsevier BV
VL 271
UT 000828178400006
DI 10.1016/j.cbpa.2022.111260
ID 89205
ER

EF