FN Archimer Export Format
PT J
TI Asperopiperazines A and B: Antimicrobial and Cytotoxic Dipeptides from a Tunicate-Derived Fungus Aspergillus sp. DY001
BT 
AF YOUSSEF, Diaa T. A.
   SHAALA, Lamiaa A.
   GENTA-JOUVE, Gregory
AS 1:1;2:2,3;3:4;
FF 1:;2:;3:;
C1 King Abdulaziz Univ, Fac Pharm, Dept Nat Prod, Jeddah 21589, Saudi Arabia.
   Natural Products Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia
   Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia
   UAR3456 CNRS LEEISA, Laboratoire Ecologie, Evolution, Interactions des Systèmes Amazoniens, Centre de Recherche de Montabo, IRD, 275 Route de Montabo, CEDEX BP 70620, 97334 Cayenne, France
C2 UNIV KING ABDULLAH KAUST, SAUDI ARABIA
   UNIV KING ABDULLAH KAUST, SAUDI ARABIA
   UNIV KING ABDULLAH KAUST, SAUDI ARABIA
   IRD, FRANCE
UM LEEISA
IN WOS Cotutelle UMR
   DOAJ
   copubli-int-hors-europe
IF 5.4
TC 5
UR https://archimer.ifremer.fr/doc/00786/89823/95399.pdf
   https://archimer.ifremer.fr/doc/00786/89823/95400.zip
LA English
DT Article
DE ;red sea tunicate;Didemnum sp;associated fungi;Aspergillus sp;DY001;marine dipeptides;asperopiperazines A and B;antimicrobial activity;cell lines' growth inhibition
AB Investigation of the cytotoxic fractions of the ethyl acetate extract of the fermentation broth of the tunicate-derived Aspergillus sp. DY001 afforded two new dipeptides, asperopiperazines A and B (1 and 2), along with the previously reported compounds (+)-citreoisocoumarin (3) and (-)-6,8-di-O-methylcitreoisocoumarin (4). Analyses of the 1D and 2D NMR spectroscopic data of the compounds supported their structural assignments. Asperopiperazine A (1) is a cyclic dipeptide of leucine and phenylalanine moieties, which are substituted with an N-methyl and an N-acetyl group, respectively. On the other hand, asperopiperazine B (2) is a cyclic dipeptide of proline and phenylalanine moieties with a hydroxyl group at C-2 of the proline part. The absolute configuration of the amino acid moieties in 1 and 2 were determined by Marfey's analyses and DFT NMR chemical shift calculations, leading to their assignment as cyclo(l-NMe-Leu-l-NAc-Phe) and cyclo(d-6-OH-Pro-l-Phe), respectively. Asperopiperazines A and B displayed higher antimicrobial effects against Escherichia coli and Staphylococcus aureus than Candida albicans. Furthermore, compounds 1-4 displayed variable growth inhibitory effects towards HCT 116 and MDA-MB-231 cells, with asperopiperazine A as the most active one towards HCT 116. 
PY 2022
PD JUN
SO Marine Drugs
SN 1660-3397
PU Mdpi
VL 20
IS 7
UT 000833308300001
DI 10.3390/md20070451
ID 89823
ER

EF