FN Archimer Export Format
PT J
TI Whole-transcriptome response to wastewater treatment plant and stormwater effluents in the Asian clam, Corbicula fluminea
BT 
AF BERTUCCI, Anthony
   PIERRON, Fabien
   GOURVES, Pierre-Yves
   KLOPP, Christophe
   LAGARDE, Gauthier
   PERETO, Clement
   DUFOUR, Vincent
   GONZALEZ, Patrice
   COYNEL, Alexandra
   BUDZINSKI, Helene
   BAUDRIMONT, Magalie
AS 1:1;2:1;3:1;4:2;5:1;6:1;7:1;8:1;9:1;10:1;11:1;
FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;11:;
C1 Univ. Bordeaux, UMR EPOC CNRS 5805, 33615 Pessac, France
   Plate-forme bio-informatique Genotoul, Mathématiques et Informatique Appliquées de Toulouse, INRA, 31326 Castanet-Tolosan, France
C2 UNIV BORDEAUX, FRANCE
   INRA, FRANCE
IF 4.527
TC 16
UR https://archimer.ifremer.fr/doc/00792/90392/95971.pdf
LA English
DT Article
DE ;Transcriptomics;Wastewater treatment plant;Urban runoff;Water quality;In-situ exposure;Corbicula fluminea
AB The increase in human population and urbanization are resulting in an increase in the volume of wastewater and urban runoff effluents entering natural ecosystems. These effluents may contain multiple pollutants to which the biological response of aquatic organisms is still poorly understood mainly due to mixture toxicity and interactions with other environmental factors. In this context, RNA sequencing was used to assess the impact of a chronic exposure to wastewater treatment plant and stormwater effluents at the whole-transcriptome level and evaluate the potential physiological outcomes in the Asian clam Corbicula fiuminea. We de-novo assembled a transcriptome from C. fluminea digestive gland and identified a set of 3,181 transcripts with altered abundance in response to water quality. The largest differences in transcriptomic profiles were observed between C. fiuminea from the reference site and those exposed to wastewater treatment plant effluents. On both anthropogenically impacted sites, most differentially expressed transcripts were involved in signaling pathways in relation to energy metabolism such as mTOR and FoxO, suggesting an energy/nutrient deficit and hypoxic conditions. These conditions were likely responsible for damages to proteins and transcripts in response to wastewater treatment effluents whereas exposure to urban runoff might result in immune and endocrine disruptions. In absence of comprehensive chemical characterization, the RNAseq approach could provide information regarding the mode of action of pollutants and then be useful for the identification of which parameters must be studied at higher integration level in order to diagnose sites where the presence of complex and variable mixtures of chemicals is suspected. 
PY 2018
PD DEC
SO Ecotoxicology And Environmental Safety
SN 0147-6513
PU Academic Press Inc Elsevier Science
VL 165
UT 000447484000012
BP 96
EP 106
DI 10.1016/j.ecoenv.2018.08.090
ID 90392
ER

EF