FN Archimer Export Format
PT J
TI Transfer and Transcriptomic Profiling in Liver and Brain of European Eels (Anguilla anguilla) After Diet-borne Exposure to Gold Nanoparticles
BT 
AF PERRIER, Fanny
   BERTUCCI, Anthony
   PIERRON, Fabien
   FEURTET-MAZEL, Agnes
   SIMON, Olivier
   KLOPP, Christophe
   CANDAUDAP, Frederic
   POKROVSKI, Oleg
   ETCHEVERRIA, Bruno
   MORNET, Stephane
   BAUDRIMONT, Magalie
AS 1:1;2:1;3:1;4:1;5:2;6:3;7:4;8:4;9:1;10:5;11:1;
FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;11:;
C1 Université de Bordeaux, CNRS, UMR EPOC 5805, Arcachon, France
   LECO, IRSN, PSE ENV, SRTE, Cadarache, Saint‐Paul‐lez‐Durance Cedex, France
   Plate‐forme bio‐informatique Genotoul, Mathématiques et Informatique Appliquées de Toulouse, INRA, Castanet‐Tolosan, France
   Université de Toulouse, CNRS, GET, UMR 5563, Toulouse, France
   Université de Bordeaux, CNRS, Bordeaux INP, ICMCB, UMR 5026, Pessac, France Abstract:
C2 UNIV BORDEAUX, FRANCE
   CEA, FRANCE
   INRA, FRANCE
   UNIV TOULOUSE, FRANCE
   UNIV BORDEAUX, FRANCE
IF 3.742
TC 2
UR https://archimer.ifremer.fr/doc/00792/90393/95972.pdf
LA English
DT Article
DE ;Gold nanoparticles;Anguilla anguilla;RNA sequencing;Diet-borne exposure;Immunity
AB A nanometric revolution is underway, promising technical innovations in a wide range of applications and leading to a potential boost in environmental discharges. The propensity of nanoparticles (NPs) to be transferred throughout trophic chains and to generate toxicity was mainly assessed in primary consumers, whereas a lack of knowledge for higher trophic levels persists. The present study focused on a predatory fish, the European eel (Anguilla anguilla) exposed to gold NPs (AuNPs; 10 nm, polyethylene glycol-coated) for 21 d at 3 concentration levels in food: 0 (NP0), 1 (NP1), and 10 (NP10) mg Au kg(-1). Transfer was assessed by Au quantification in eel tissues, and transcriptomic responses in the liver and brain were revealed by a high-throughput RNA-sequencing approach. Eels fed at NP10 presented an erratic feeding behavior, whereas Au quantification only indicated transfer to intestine and kidney of NP1-exposed eels. Sequencing of RNA was performed in NP0 and NP1 eels. A total of 258 genes and 156 genes were significantly differentially transcribed in response to AuNP trophic exposure in the liver and brain, respectively. Enrichment analysis highlighted modifications in the immune system-related processes in the liver. In addition, results pointed out a shared response of both organs regarding 13 genes, most of them being involved in immune functions. This finding may shed light on the mode of action and toxicity of AuNPs in fish. 
PY 2020
PD DEC
SO Environmental Toxicology And Chemistry
SN 0730-7268
PU Wiley
VL 39
IS 12
UT 000577675500001
BP 2450
EP 2461
DI 10.1002/etc.4858
ID 90393
ER

EF