Carotenoids from Marine Microalgae as Antimelanoma Agents
Type | Article | ||||||||
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Date | 2022-10 | ||||||||
Language | English | ||||||||
Author(s) | Adrielly Alves Ferraz Christiane1, Grougnet Raphaël1, Nicolau Elodie2, Picot Laurent3, Gonçalves De Oliveira Junior Raimundo1 | ||||||||
Affiliation(s) | 1 : UMR 8038 CiTCoM, Faculté de Santé, UFR Pharmacie, Université Paris Cité, 75006 Paris, France 2 : Laboratoire PHYTOX/GENALG, IFREMER, 44311 Nantes, France 3 : UMR CNRS 7266 LIENSs, La Rochelle Université, 17042 La Rochelle, France |
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Source | Marine Drugs (1660-3397) (MDPI AG), 2022-10 , Vol. 20 , N. 10 , P. 618 (26p.) | ||||||||
DOI | 10.3390/md20100618 | ||||||||
WOS© Times Cited | 2 | ||||||||
Note | This article belongs to the Special Issue Development and Application of Marine-Derived Anti-cancer Agents | ||||||||
Keyword(s) | marine carotenoids, marine pigments, melanoma, pigments, skin cancer | ||||||||
Abstract | Melanoma cells are highly invasive and metastatic tumor cells and commonly express molecular alterations that contribute to multidrug resistance (e.g., BRAFV600E mutation). Conventional treatment is not effective in a long term, requiring an exhaustive search for new alternatives. Recently, carotenoids from microalgae have been investigated as adjuvant in antimelanoma therapy due to their safety and acceptable clinical tolerability. Many of them are currently used as food supplements. In this review, we have compiled several studies that show microalgal carotenoids inhibit cell proliferation, cell migration and invasion, as well as induced cell cycle arrest and apoptosis in various melanoma cell lines. MAPK and NF-ĸB pathway, MMP and apoptotic factors are frequently affected after exposure to microalgal carotenoids. Fucoxanthin, astaxanthin and zeaxanthin are the main carotenoids investigated, in both in vitro and in vivo experimental models. Preclinical data indicate these compounds exhibit direct antimelanoma effect but are also capable of restoring melanoma cells sensitivity to conventional chemotherapy (e.g., vemurafenib and dacarbazine). |
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