FN Archimer Export Format
PT J
TI Limited Transmission of Klebsiella pneumoniae among Humans, Animals, and the Environment in a Caribbean Island, Guadeloupe (French West Indies)
BT 
AF Dereeper, Alexis
   Gruel, Gaëlle
   Pot, Matthieu
   Couvin, David
   Barbier, Elodie
   Bastian, Sylvaine
   Bambou, Jean-Christophe
   Gelu-Simeon, Moana
   Ferdinand, Séverine
   Guyomard-Rabenirina, Stéphanie
   Passet, Virginie
   Martino, Frederic
   Piveteau, Pascal
   Reynaud, Yann
   Rodrigues, Carla
   Roger, Pierre-Marie
   Roy, Xavier
   Talarmin, Antoine
   Tressieres, Benoit
   Valette, Marc
   Brisse, Sylvain
   Breurec, Sébastien
AS 1:1;2:1;3:1;4:1;5:2;6:3;7:4;8:5;9:1;10:1;11:6;12:7;13:8;14:1;15:6;16:9,10;17:11;18:1;19:12;20:7;21:6;22:1,3,10,12;
FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;11:;12:;13:;14:;15:;16:;17:;18:;19:;20:;21:;22:;
C1 Transmission, Reservoir and Diversity of Pathogens Unit, Pasteur Institute of Guadeloupe, Pointe-à-Pitre, France
   UMR AgroEcologie, INRAE, Bourgogne Franche-Comté University, Dijon, France
   Laboratory of Clinical Microbiology, University Hospital Center of Guadeloupe, Pointe-à-Pitre/Les Abymes, France
   INRAE, ASSET, Petit-Bourg, France
   Hepato-Gastroenterology Department, University Hospital Center of Guadeloupe, Pointe-à-Pitre/Les Abymes, France
   Institut Pasteur, University Paris Cité, Biodiversity and Epidemiology of Bacterial Pathogens, Paris, France
   Intensive Care Department, University Hospital Center of Guadeloupe, Pointe-à-Pitre/Les Abymes, France
   UR OPAALE, INRAE, Rennes, France
   Infectious Disease Department, University Hospital Center of Guadeloupe, Pointe-à-Pitre/Les Abymes, France
   Faculty of Medecine Hyacinthe Bastaraud, University of the Antilles, Pointe-à-Pitre, France
   Veterinary Clinic, Baie-Mahault, Guadeloupe
   INSERM Center for Clinical Investigation 1424, Pointe-à-Pitre/Les Abymes, France
C2 INST PASTEUR, FRANCE
   INRAE, FRANCE
   CHU GUADELOUPE, FRANCE
   INRAE, FRANCE
   CHU GUADELOUPE, FRANCE
   INST PASTEUR, FRANCE
   CHU GUADELOUPE, FRANCE
   INRAE, FRANCE
   CHU GUADELOUPE, FRANCE
   UNIV ANTILLES, FRANCE
   VETERINARY CLINIC, FRANCE
   INSERM, FRANCE
IN DOAJ
IF 3.7
TC 0
UR https://archimer.ifremer.fr/doc/00800/91237/96993.pdf
   https://archimer.ifremer.fr/doc/00800/91237/96994.pdf
   https://archimer.ifremer.fr/doc/00800/91237/96995.xlsx
   https://archimer.ifremer.fr/doc/00800/91237/96996.xls
   https://archimer.ifremer.fr/doc/00800/91237/96997.xlsx
LA English
DT Article
AB Guadeloupe (French West Indies), a Caribbean island, is an ideal place to study the reservoirs of the Klebsiella pneumoniae species complex (KpSC) and identify the routes of transmission between human and nonhuman sources due to its insularity, small population size, and small area. Here, we report an analysis of 590 biological samples, 546 KpSC isolates, and 331 genome sequences collected between January 2018 and May 2019. The KpSC appears to be common whatever the source. Extended-spectrum-β-lactamase (ESBL)-producing isolates (21.4%) belonged to K. pneumoniae sensu stricto (phylogroup Kp1), and all but one were recovered from the hospital setting. The distribution of species and phylogroups across the different niches was clearly nonrandom, with a distinct separation of Kp1 and Klebsiella variicola (Kp3). The most frequent sequence types (STs) (≥5 isolates) were previously recognized as high-risk multidrug-resistant (MDR) clones, namely, ST17, ST307, ST11, ST147, ST152, and ST45. Only 8 out of the 63 STs (12.7%) associated with human isolates were also found in nonhuman sources. A total of 22 KpSC isolates were defined as hypervirulent: 15 associated with human infections (9.8% of all human isolates), 4 (8.9%) associated with dogs, and 3 (15%) associated with pigs. Most of the human isolates (33.3%) belonged to the globally successful sublineage CG23-I. ST86 was the only clone shared by a human and a nonhuman (dog) source. Our work shows the limited transmission of KpSC isolates between human and nonhuman sources and points to the hospital setting as a cornerstone of the spread of MDR clones and antibiotic resistance genes. 
PY 2022
PD OCT
SO Microbiology Spectrum
SN 2165-0497
PU American Society for Microbiology
VL 10
IS 5
DI 10.1128/spectrum.01242-22
ID 91237
ER

EF