FN Archimer Export Format
PT J
TI Juvenile zebrafish (Danio rerio) are able to recover from lordosis
BT 
AF Printzi, Aliki
   Mazurais, David
   Witten, P. E.
   Madec, Lauriane
   Gonzalez, A.-A.
   Mialhe, X.
   ZAMBONINO INFANTE, Jose-Luis
   Koumoundouros, G.
AS 1:1,2;2:2;3:3;4:2;5:4;6:4;7:2;8:1;
FF 1:PDG-RBE-PFOM-LARN;2:PDG-RBE-PFOM-LARN;3:;4:PDG-RBE-PFOM-LARN;5:;6:;7:PDG-RBE-PFOM;8:;
C1 Biology Department, University of Crete, Crete, Greece
   IFREMER, University of Brest, CNRS, IRD, LEMAR, 29280, Plouzané, France
   Department of Biology, Gent University, Gent, Belgium
   MGX-Montpellier GenomiX, CNRS, INSERM, Univ. Montpellier, Montpellier, France
C2 UNIV CRETE, GREECE
   IFREMER, FRANCE
   UNIV GHENT, BELGIUM
   CNRS, FRANCE
SI BREST
SE PDG-RBE-PFOM-LARN
   PDG-RBE-PFOM
UM LEMAR
IN WOS Ifremer UMR
   DOAJ
   copubli-france
   copubli-europe
IF 4.6
TC 4
UR https://archimer.ifremer.fr/doc/00810/92221/98207.pdf
   https://archimer.ifremer.fr/doc/00810/92221/98208.xlsx
   https://archimer.ifremer.fr/doc/00810/92221/98209.xlsx
   https://archimer.ifremer.fr/doc/00810/92221/98210.xlsx
   https://archimer.ifremer.fr/doc/00810/92221/98211.xlsx
   https://archimer.ifremer.fr/doc/00810/92221/98212.docx
   https://archimer.ifremer.fr/doc/00810/92221/98213.jpg
   https://archimer.ifremer.fr/doc/00810/92221/98214.jpg
LA English
DT Article
AB Haemal lordosis, a frequent skeletal deformity in teleost fish, has long been correlated with increased mechanical loads induced by swimming activity. In the present study, we examine whether juvenile zebrafish can recover from haemal lordosis and explore the musculoskeletal mechanisms involved. Juveniles were subjected to a swimming challenge test (SCT) that induced severe haemal lordosis in 49% of the animals and then immediately transferred them to 0.0 total body lengths (TL) per second of water velocity for a week. The recovery from lordosis was examined by means of whole mount staining, histology and gene expression analysis. Results demonstrate that 80% of the lordotic zebrafish are capable of internal and external recovery within a week after the SCT. Recovered individuals presented normal shape of the vertebral centra, maintaining though distorted internal tissue organization. Through the transcriptomic analysis of the affected haemal regions, several processes related to chromosome organization, DNA replication, circadian clock and transcription regulation were enriched within genes significantly regulated behind this musculoskeletal recovery procedure. Genes especially involved in adipogenesis, bone remodeling and muscular regeneration were regulated. A remodeling tissue-repair hypothesis behind haemal lordosis recovery is raised. Limitations and future possibilities for zebrafish as a model organism to clarify mechanically driven musculoskeletal changes are discussed. 
PY 2022
PD DEC
SO Scientific Reports
SN 2045-2322
PU Springer Science and Business Media LLC
VL 12
IS 1
UT 000929919800001
DI 10.1038/s41598-022-26112-2
ID 92221
ER

EF