FN Archimer Export Format
PT J
TI Glycosaminoglycan Mimetics Obtained by Microwave-Assisted Sulfation of Marine Bacterium Sourced Infernan Exopolysaccharide
BT 
AF Colliec-Jouault, Sylvia
   Esposito, Fabiana
   Ledru, Hélène
   Sinquin, Corinne
   Marchand, Laetitia
   Fillaudeau, Arnaud
   Routier, Sylvain
   Buron, Frédéric
   Lopin-Bon, Chrystel
   Cuenot, Stéphane
   Bedini, Emiliano
   Zykwinska, Agata
AS 1:1;2:2;3:3;4:1;5:1;6:1;7:3;8:3;9:3;10:4;11:2;12:1;
FF 1:PDG-RBE-MASAE-LEMMMB;2:;3:;4:PDG-RBE-MASAE-LEMMMB;5:PDG-RBE-MASAE-LEMMMB;6:PDG-RBE-MASAE-LEMMMB;7:;8:;9:;10:;11:;12:PDG-RBE-MASAE-LEMMMB;
C1 Ifremer, MASAE Microbiologie Aliment Santé Environnement, F-44000Nantes, France
   Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte S.Angelo, via Cintia 4, I-80126Napoli, Italy
   Institut de Chimie Organique et Analytique─UMR 7311, Université d’Orléans et CNRS, Rue de Chartres, BP 6759, 45067Orléans Cedex 2, France
   Institut des Matériaux Jean Rouxel─IMN, Nantes Université and CNRS, Nantes44322, France
C2 IFREMER, FRANCE
   UNIV NAPLES, ITALY
   UNIV ORLEANS, FRANCE
   UNIV NANTES, FRANCE
SI NANTES
SE PDG-RBE-MASAE-LEMMMB
IN WOS Ifremer UPR
   copubli-france
   copubli-europe
   copubli-univ-france
IF 6.2
TC 4
UR https://archimer.ifremer.fr/doc/00813/92487/99070.pdf
LA English
DT Article
AB Sulfated glycosaminoglycans (GAGs) are fundamental constituents of both the cell surface and extracellular matrix. By playing a key role in cell–cell and cell–matrix interactions, GAGs are involved in many physiological and pathological processes. To design GAG mimetics with similar therapeutic potential as the natural ones, the specific structural features, among them sulfate content, sulfation pattern, and chain length, should be considered. In the present study, we describe a sulfation method based on microwave radiation to obtain highly sulfated derivatives as GAG mimetics. The starting low-molecular-weight (LMW) derivative was prepared from the infernan exopolysaccharide, a highly branched naturally slightly sulfated heteropolysaccharide synthesized by the deep-sea hydrothermal vent bacterium Alteromonas infernus. LMW highly sulfated infernan derivatives obtained by conventional heating sulfation have already been shown to display GAG-mimetic properties. Here, the potential of microwave-assisted sulfation versus that of the conventional method to obtain GAG mimetics was explored. Structural analysis by NMR revealed that highly sulfated derivatives from the two methods shared similar structural features, emphasizing that microwave-assisted sulfation with a 12-fold shorter reaction time is as efficient as the classical one. 
PY 2023
PD JAN
SO Biomacromolecules
SN 1525-7797
PU American Chemical Society (ACS)
VL 24
IS 1
UT 000905365500001
BP 462
EP 470
DI 10.1021/acs.biomac.2c01277
ID 92487
ER

EF