FN Archimer Export Format
PT J
TI Anti-Biofilm Activity of a Hyaluronan-like Exopolysaccharide from the Marine Vibrio MO245 against Pathogenic Bacteria
BT 
AF CHAMPION, Marie
   PORTIER, Emilie
   VALLEE-REHEL, Karine
   LINOSSIER, Isabelle
   BALNOIS, Eric
   VIGNAUD, Guillaume
   MOPPERT, Xavier
   HELLIO, Claire
   FAY, Fabienne
AS 1:1;2:1;3:1;4:1;5:2;6:3;7:4;8:5;9:1;
FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;
C1 Laboratoire de Biotechnologies et Chimie Marines, EA3884, Université Bretagne Sud, 56321 Lorient, France
   Laboratoire de Biotechnologies et Chimie Marines, EA3884, Université de Bretagne Occidentale, 29000 Quimper, France
   Institut de Recherche Dupuy de Lôme (IRDL), UMR CNRS 6027, Université Bretagne Sud, 56321 Lorient, France
   Pacific Biotech, BP 140 289, 98701 Arue, France
   Biodimar, LEMAR UMR6539, Institut Européen de la Mer, Université Bretagne Occidentale, 29238 Brest, France
C2 UBS, FRANCE
   UBO, FRANCE
   UBS, FRANCE
   PACIFIC BIOTECH, FRANCE
   UBO, FRANCE
UM LEMAR
IN WOS Cotutelle UMR
   DOAJ
   copubli-france
   copubli-univ-france
TC 4
UR https://archimer.ifremer.fr/doc/00819/93107/99587.pdf
LA English
DT Article
DE ;exopolysaccharide;anti-adhesive activity;anti-biofilm activity;marine bacteria;non biocidal agent;Pseudomonas aeruginosa;Vibrio harveyi
AB Biofilms, responsible for many serious drawbacks in the medical and marine environment, can grow on abiotic and biotic surfaces. Commercial anti-biofilm solutions, based on the use of biocides, are available but their use increases the risk of antibiotic resistance and environmental pollution in marine industries. There is an urgent need to work on the development of ecofriendly solutions, formulated without biocidal agents, that rely on the anti-adhesive physico-chemical properties of their materials. In this context, exopolysaccharides (EPSs) are natural biopolymers with complex properties than may be used as anti-adhesive agents. This study is focused on the effect of the EPS MO245, a hyaluronic acid-like polysaccharide, on the growth, adhesion, biofilm maturation, and dispersion of two pathogenic model strains, Pseudomonas aeruginosa sp. PaO1 and Vibrio harveyi DSM19623. Our results demonstrated that MO245 may limit biofilm formation, with a biofilm inhibition between 20 and 50%, without any biocidal activity. Since EPSs have no significant impact on the bacterial motility and quorum sensing factors, our results indicate that physico-chemical interactions between the bacteria and the surfaces are modified due to the presence of an adsorbed EPS layer acting as a non-adsorbing layer.
PY 2022
PD NOV
SO Marine Drugs
PU Mdpi
VL 20
IS 11
UT 000910907500001
DI 10.3390/md20110728
ID 93107
ER

EF