FN Archimer Export Format
PT J
TI Effects of 17α-ethinylestradiol on the neuroendocrine gonadotropic system and behavior of European sea bass larvae (Dicentrarchus labrax)
BT 
AF Solperto, S.
   Olivier, S.
   Poret, A
   Minier, C.
   HALM-LEMEILLE, Marie-Pierre
   Jozet-Alves, C.
   Aroua, S.
AS 1:1;2:1;3:1;4:1;5:2;6:3,4;7:1;
FF 1:;2:;3:;4:;5:PDG-ODE-LITTORAL;6:;7:;
C1 Normandie Univ, UNIHAVRE, Le Havre Cedex, France
   Ifremer Port-en-Bessin, Laboratoire Environnement Ressources de Normandie, Port-en- Bessin, France
   Normandie Univ, Unicaen, CNRS, Caen, France
   Univ Rennes, CNRS, Rennes, France
C2 UNIV LE HAVRE NORMANDIE, FRANCE
   IFREMER, FRANCE
   UNIV CAEN NORMANDIE, FRANCE
   UNIV RENNES, FRANCE
SI PORT-EN-BESSIN
SE PDG-ODE-LITTORAL
IN WOS Ifremer UPR
   copubli-france
   copubli-univ-france
IF 2.6
TC 0
UR https://archimer.ifremer.fr/doc/00821/93301/109473.pdf
LA English
DT Article
AB The widespread use of 17α-ethinylestradiol (EE2), and other estrogenic endocrine disruptors, results in a continuous release of estrogenic compounds into aquatic environments. Xenoestrogens may interfere with the neuroendocrine system of aquatic organisms and may produce various adverse effects. The aim of the present study was to expose European sea bass larvae (Dicentrarchus labrax) to EE2 (0.5 and 50 nM) for 8 d and determine the expression levels of brain aromatase (cyp19a1b), gonadotropin-releasing hormones (gnrh1, gnrh2, gnrh3), kisspeptins (kiss1, kiss2) and estrogen receptors (esr1, esr2a, esr2b, gpera, gperb). Growth and behavior of larvae as evidenced by locomotor activity and anxiety-like behaviors were measured 8 d after EE2 treatment and a depuration period of 20 d. Exposure to 0.5 nM EE2 induced a significant increase in cyp19a1b expression levels, while upregulation of gnrh2, kiss1, and cyp19a1b expression was noted after 8 d at 50 nM EE2. Standard length at the end of the exposure phase was significantly lower in larvae exposed to 50 nM EE2 than in control; however, this effect was no longer observed after the depuration phase. The upregulation of gnrh2, kiss1, and cyp19a1b expression levels was found in conjunction with elevation in locomotor activity and anxiety-like behaviors in larvae. Behavioral alterations were still detected at the end of the depuration phase. Evidence indicates that the long-lasting effects of EE2 on behavior might impact normal development and subsequent fitness of exposed fish. 
PY 2023
PD MAR
SO Journal Of Toxicology And Environmental Health-part A-current Issues
SN 1528-7394
PU Taylor and Francis
VL 86
IS 6
UT 000936066200001
BP 198
EP 215
DI 10.1080/15287394.2023.2177781
ID 93301
ER

EF