FN Archimer Export Format
PT J
TI Comparison of Sodium Selenite and Selenium-Enriched Spirulina Supplementation Effects After Selenium Deficiency on Growth, Tissue Selenium Concentrations, Antioxidant Activities, and Selenoprotein Expression in Rats
BT 
AF Castel, Thomas
   Léon, Karelle
   Gandubert, Charlotte
   Gueguen, Bleuenn
   Amérand, Aline
   Guernec, Anthony
   Théron, Michaël
   Pichavant-Rafini, Karine.
AS 1:1;2:1;3:1;4:2,3;5:1;6:1;7:1;8:1;
FF 1:;2:;3:;4:;5:;6:;7:;8:;
C1 Université de Brest, EA 4324 ORPHY, UFR Sciences et Techniques, 6 avenue Victor Le Gorgeu, F-29200, Brest, France
   CNRS, Univ Brest, UMS 3113, F-29280, Plouzané, France
   CNRS, Univ Brest, UMR 6538 Laboratoire Géosciences Océan, F-29280, Plouzané, France
C2 UBO, FRANCE
   CNRS, FRANCE
   CNRS, FRANCE
UM GEO-OCEAN
IN WOS Cotutelle UMR
   copubli-france
   copubli-univ-france
IF 3.9
TC 2
UR https://archimer.ifremer.fr/doc/00838/94999/102606.pdf
LA English
DT Article
DE ;Selenium;Spirulina;Selenoproteins;Antioxidant activities;Rat
AB Selenium contributes to physiological functions through its incorporation into selenoproteins. It is involved in oxidative stress defense. A selenium deficiency results in the onset or aggravation of pathologies. Following a deficiency, the repletion of selenium leads to a selenoprotein expression hierarchy misunderstood. Moreover, spirulina, a microalga, exhibits antioxidant properties and can be enriched in selenium.. Our objective was to determine the effects of a sodium selenite or selenium-enriched spirulina supplementation. Thirty-two female Wistar rats were fed for 12 weeks with a selenium-deficient diet. After 8 weeks, rats were divided into 4 groups and were fed with water, sodium selenite (20 μg Se/kg body weight), spirulina (3 g/kg bw), or selenium-enriched spirulina (20 μg Se/kg bw + 3 g spirulina/kg bw). Another group of 8 rats was fed with normal diet during 12 weeks. Selenium concentration and antioxidant enzyme activities were measured in plasma, urine, liver, brain, kidney, heart, and soleus. Expression of GPx (1, 3), Sel (P, S, T, W), SEPHS2, TrxR1, ApoER2, and megalin were quantified in liver, kidney, brain, and heart. We showed that a selenium deficiency leads to a growth delay, reversed by selenium supplementation despite a minor loss of weight in week 12 for SS rats. All tissues displayed a decrease in selenium concentration following deficiency. The brain seemed protected. We demonstrated a hierarchy in selenium distribution and selenoprotein expression. A supplementation of sodium selenite improved GPx activities and selenoprotein expression while a selenium-enriched spirulina was more effective to restore selenium concentration especially in the liver, kidney, and soleus. 
PY 2024
PD FEB
SO Biological Trace Element Research
SN 0163-4984
PU Springer Science and Business Media LLC
VL 202
IS 2
UT 000989312700001
BP 685
EP 700
DI 10.1007/s12011-023-03705-0
ID 94999
ER

EF