FN Archimer Export Format
PT J
TI Balancing selection at a wing pattern locus is associated with major shifts in genome-wide patterns of diversity and gene flow
BT 
AF Rodríguez de Cara, María Ángeles
   Jay, Paul
   Rougemont, Quentin
   Chouteau, Mathieu
   Whibley, Annabel
   Huber, Barbara
   Piron-Prunier, Florence
   Ramos, Renato Rogner
   Freitas, André V. L.
   Salazar, Camilo
   Silva-Brandão, Karina Lucas
   Torres, Tatiana Teixeira
   Joron, Mathieu
AS 1:1;2:1;3:1;4:1,2;5:3,4;6:5;7:3;8:6;9:6;10:7;11:8;12:9;13:1;
FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;11:;12:;13:;
C1 Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Univ Montpellier, CNRS, EPHE, IRD, Montpellier, France
   Laboratoire Ecologie, Evolution, Interactions Des Systèmes Amazoniens (LEEISA), Université de Guyane, IFREMER, CNRS, Cayenne, Guyane Française
   Institut de Systématique Evolution Biodiversité (ISYEB), Museum National d’Histoire Naturelle, CNRS, Sorbonne-Université, EPHE, Université des Antilles, Paris, France
   School of Biological Sciences, University of Auckland, Auckland, New Zealand
   Instituto de Ciencias Ecológicas y Ambientales (ICAE), Univ de los Andes, Mérida, Venezuela
   Departamento de Biologia Animal, Instituto de Biologia, Unicamp, Campinas, São Paulo, Brazil
   Department of Biology, Faculty of Natural Sciences, Universidad del Rosario, Carrera 24 No 63C- 69, Bogotá 111221, Colombia
   Museum of Nature Hamburg, Leibniz Institute for the Analysis of Biodiversity Change. Martin-Luther-King-Platz 3, 20146 Hamburg, Germany
   Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo (USP), São Paulo, Brazil
C2 UNIV MONTPELLIER, FRANCE
   UNIV GUYANE, FRANCE
   MNHN, FRANCE
   UNIV AUCKLAND, NEW ZEALAND
   UNIV LOS ANDES, VENEZUELA
   UNICAMP, BRAZIL
   UNIV ROSARIO BOGOTA, COLOMBIA
   MUSEUM NATURE HAMBURG, GERMANY
   UNIV SAO PAULO, BRAZIL
UM LEEISA
IN DOAJ
TC 0
UR https://archimer.ifremer.fr/doc/00840/95235/102983.pdf
   https://archimer.ifremer.fr/doc/00840/95235/102984.pdf
   https://archimer.ifremer.fr/doc/00840/95235/102985.xlsx
   https://archimer.ifremer.fr/doc/00840/95235/105410.pdf
LA English
DT Article
AB Selection shapes genetic diversity around target mutations, yet little is known about how selection on specific loci affects the genetic trajectories of populations, including their genome-wide patterns of diversity and demographic responses. Here we study the patterns of genetic variation and geographic structure in a neotropical butterfly,Heliconius numata, and its closely related allies in the so-called melpomene-silvaniform clade.H. numatais known to have evolved an inversion supergene which controls variation in wing patterns involved in mimicry associations with distinct groups of co-mimics whereas it is associated to disassortative mate preferences and heterozygote advantage at this locus. We contrasted patterns of genetic diversity and structure 1) among extant polymorphic and monomorphic populations ofH. numata, 2) betweenH. numataand its close relatives, and 3) between ancestral lineages. We show thatH. numatapopulations which carry the inversions as a balanced polymorphism show markedly distinct patterns of diversity compared to all other taxa. They show the highest genetic diversity and effective population size estimates in the entire clade, as well as a low level of geographic structure and isolation by distance across the entire Amazon basin. By contrast, monomorphic populations ofH. numataas well as its sister species and their ancestral lineages all show lower effective population sizes and genetic diversity, and higher levels of geographical structure across the continent. One hypothesis is that the large effective population size of polymorphic populations could be caused by the shift to a regime of balancing selection due to the genetic load and disassortative preferences associated with inversions. Testing this hypothesis with forward simulations supported the observation of increased diversity in populations with the supergene. Our results are consistent with the hypothesis that the formation of the supergene triggered a change in gene flow, causing a general increase in genetic diversity and the homogenisation of genomes at the continental scale. 
PY 2021
PD OCT
SO Peer Community Journal
SN 2804-3871
PU Centre Mersenne
VL 3
IS e65
DI 10.24072/pcjournal.298
ID 95235
ER

EF